Chronic myelocytic leukemia (CML): failure to detect residual normal committed stem cells in vitro

Autor:	J W, Singer, P J, Fialkow, L, Steinmann, V, Najfeld, S J, Stein, W A, Robinson
Rok vydání:	1979
Předmět:	Adult Immunology Electrophoresis Cellulose Acetate Cell Biology Hematology Glucosephosphate Dehydrogenase Middle Aged Hematopoietic Stem Cells Biochemistry Leukemia Myeloid hemic and lymphatic diseases Humans Cells Cultured Granulocytes
Zdroj:	Blood. 53:264-268
ISSN:	1528-0020 0006-4971
Popis:	Granulocytic colonies grown in culture from marrow and peripheral blood from five patients with Ph1-positive CML and heterozygous at the G-6-PD locus were analyzed for G-6-PD in order to identify CFU-C that do not arise from the CML clone. The patients had both B and A enzymes in normal tissues, but their CML clones typed as B. Whereas about 50% of colonies from normal subjects heterozygous as the G-6-PD locus show type-A G-6-PD and 50% type B, only two of the 1308 colonies from the CML patients had type-A G-6-PD. These data provide little evidence for persistence of normal committed stem cells in CML, a finding in contrast to that made previously in polycythemia vera, another clonal stem cell myeloproliferative disorder.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8206d46062dbf10721b9683667f0492 https://doi.org/10.1182/blood.v53.2.264.bloodjournal532264 Zobrazit plný text záznamu