Specifications of a neutron exposure accelerator system for biological effects experiments (NASBEE) in NIRS

Autor: Takuya Hagihara, Shizuko Kakinuma, Teruaki Konishi, Hitoshi Imaseki, M. Suda, Yoshiya Shimada, Yasushi Ohmachi, Noriyoshi Suya, Kentaro Ariyoshi, Takeshi Maeda, Tsuyoshi Hamano, Masashi Takada
Rok vydání: 2009
Předmět:
Zdroj: Radiation Physics and Chemistry. 78:1216-1219
ISSN: 0969-806X
DOI: 10.1016/j.radphyschem.2009.05.010
Popis: We developed a neutron irradiation facility, neutron exposure accelerator system for biological effect experiments (NASBEE) for biological studies in National Institute of Radiological Sciences, Japan. Irradiation field of 2 MeV average neutrons generated by a Be(d–n)B reaction is established. Dose uniformity of 240 mm in diameter irradiation field is producible within ±2.5% with a dose rate of 0.87 Gy/h at sample target distance of 1170 mm. Two irradiation rooms, a specific pathogen-free (SPF) conditioned one and a conventional, are now available. Irradiation protocols for in vitro experiments are now established and demonstrated by obtaining a relative biological effectiveness (RBE) of cell inactivation measured to be 3.54 with 10% survival dose ( D 10 ).
Databáze: OpenAIRE