State, trait and biochemical influences on human anterior cingulate function

Autor: R. Mark Wellard, Christos Pantelis, Murat Yücel, Stephen J. Wood, Ben J. Harrison, Kerrie Clarke, Alex Fornito, Sue M. Cotton
Rok vydání: 2007
Předmět:
Dorsum
Adult
Male
060104 Cell Metabolism
Cognitive Neuroscience
media_common.quotation_subject
Intelligence
110903 Central Nervous System
111714 Mental Health
behavioral disciplines and activities
Brain mapping
Gyrus Cinguli
Functional Laterality
Conflict
Psychological

Neuroimaging
170112 Sensory Processes Perception and Performance
medicine
111601 Cell Physiology
Personality
Humans
Anterior cingulate cortex
media_common
110904 Neurology and Neuromuscular Diseases
Neurons
110902 Cellular Nervous System
Aspartic Acid
Brain Mapping
100402 Medical Biotechnology Diagnostics (incl. Biosensors)
060603 Animal Physiology - Systems
Mental Disorders
Wechsler Scales
Wechsler Adult Intelligence Scale
Cognition
Middle Aged
110319 Psychiatry (incl. Psychotherapy)
Magnetic Resonance Imaging
medicine.anatomical_structure
Neurology
170101 Biological Psychology (Neuropsychology Psychopharmacology Physiological Psychology)
Trait
170205 Neurocognitive Patterns and Neural Networks
060105 Cell Neurochemistry
Female
Nervous System Diseases
Psychology
psychological phenomena and processes
Cognitive psychology
Zdroj: Neuroimage
ISSN: 2381-3652
Popis: The dorsal part of the human anterior cingulate cortex (dACC) is reliably activated in situations requiring cognitive control, especially during states of conflict. However, little is known about how individual differences in the neural characteristics of the dACC and major dimensions of behavior, affect this brain response. We recruited 28 healthy adults and employed a multi-modal neuroimaging approach combined with a task designed to specifically activate the human dACC and statistical path analysis to demonstrate clear roles for intelligence, personality and concentrations of neuronal N-acetylaspartate in determining dACC activation. These influences were comparable in magnitude to those associated with the experience of conflict. Our findings extend current understandings of the neural substrates of cognitive control by modeling the effect of neuronal viability, intelligence, and personality, on dACC activation. They also highlight the importance of considering enduring personal characteristics when mapping human brain-behavior relationships.
Databáze: OpenAIRE