State, trait and biochemical influences on human anterior cingulate function
Autor: | R. Mark Wellard, Christos Pantelis, Murat Yücel, Stephen J. Wood, Ben J. Harrison, Kerrie Clarke, Alex Fornito, Sue M. Cotton |
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Rok vydání: | 2007 |
Předmět: |
Dorsum
Adult Male 060104 Cell Metabolism Cognitive Neuroscience media_common.quotation_subject Intelligence 110903 Central Nervous System 111714 Mental Health behavioral disciplines and activities Brain mapping Gyrus Cinguli Functional Laterality Conflict Psychological Neuroimaging 170112 Sensory Processes Perception and Performance medicine 111601 Cell Physiology Personality Humans Anterior cingulate cortex media_common 110904 Neurology and Neuromuscular Diseases Neurons 110902 Cellular Nervous System Aspartic Acid Brain Mapping 100402 Medical Biotechnology Diagnostics (incl. Biosensors) 060603 Animal Physiology - Systems Mental Disorders Wechsler Scales Wechsler Adult Intelligence Scale Cognition Middle Aged 110319 Psychiatry (incl. Psychotherapy) Magnetic Resonance Imaging medicine.anatomical_structure Neurology 170101 Biological Psychology (Neuropsychology Psychopharmacology Physiological Psychology) Trait 170205 Neurocognitive Patterns and Neural Networks 060105 Cell Neurochemistry Female Nervous System Diseases Psychology psychological phenomena and processes Cognitive psychology |
Zdroj: | Neuroimage |
ISSN: | 2381-3652 |
Popis: | The dorsal part of the human anterior cingulate cortex (dACC) is reliably activated in situations requiring cognitive control, especially during states of conflict. However, little is known about how individual differences in the neural characteristics of the dACC and major dimensions of behavior, affect this brain response. We recruited 28 healthy adults and employed a multi-modal neuroimaging approach combined with a task designed to specifically activate the human dACC and statistical path analysis to demonstrate clear roles for intelligence, personality and concentrations of neuronal N-acetylaspartate in determining dACC activation. These influences were comparable in magnitude to those associated with the experience of conflict. Our findings extend current understandings of the neural substrates of cognitive control by modeling the effect of neuronal viability, intelligence, and personality, on dACC activation. They also highlight the importance of considering enduring personal characteristics when mapping human brain-behavior relationships. |
Databáze: | OpenAIRE |
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