Anti-inflammatory effects of royal jelly on ethylene glycol induced renal inflammation in rats
| Autor: | Laçine Aksoy, Zeyneb Aslan |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Ethylene Glycol Time Factors food.ingredient medicine.drug_class Urology Interleukin-1beta Anti-Inflammatory Agents Calcium oxalate Enzyme-Linked Immunosorbent Assay Inflammation Pharmacology lcsh:RC870-923 Nephrolithiasis medicine.disease_cause Anti-inflammatory Proinflammatory cytokine Rats Sprague-Dawley royal jelly [Supplementary Concept] chemistry.chemical_compound food Royal jelly Animals Medicine Nephritis Calcium Oxalate Tumor Necrosis Factor-alpha business.industry Fatty Acids Interleukin-18 Reproducibility of Results lcsh:Diseases of the genitourinary system. Urology Oxidative Stress Treatment Outcome chemistry Immunology Cytokines Original Article Interleukin 18 medicine.symptom business Ethylene glycol Oxidative stress |
| Zdroj: | International braz j urol v.41 n.5 2015 International Braz J Urol Sociedade Brasileira de Urologia (SBU) instacron:SBU International braz j urol, Volume: 41, Issue: 5, Pages: 1008-1013, Published: OCT 2015 International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology International Brazilian Journal of Urology, Vol 41, Iss 5, Pp 1008-1013 (2015) |
| ISSN: | 1677-5538 |
| DOI: | 10.1590/s1677-5538.ibju.2014.0470 |
| Popis: | ARTIcLE InfO Objective: In this study, anti-inflammatory effects of Royal Jelly were investigated by inducing renal inflammation in rats with the use of ethylene glycol. For this purpose, the calcium oxalate urolithiasis model was obtained by feeding rats with ethylene glycol in drinking water. Materials and Methods: The rats were divided in five study groups. The 1 st group was determined as the control group. The rats in the 2 nd group received ethylene glycol (1%) in drinking water. The rats in the 3 rd group were daily fed with Royal Jelly by using oral gavage. The 4 th group was determined as the preventive group and the rats were fed with ethylene glycol (1%) in drinking water while receiving Royal Jelly via oral gavage. The 5 th group was determined as the therapeutic group and received ethylene glycol in drinking water during the first 2 weeks of the study and Royal Jelly via oral gavage during the last 2 weeks of the study. Results: At the end of the study, proinflammatory/anti-inflammatory cytokines, TNF-α , IL-1β and IL-18 levels in blood and renal tissue samples from the rats used in the application were measured. Conclusion: The results have shown that ethylene glycol does induce inflammation and renal damage. This can cause the formation of reactive oxygen species. Royal Jelly is also considered to have anti-inflammatory effects due to its possible antiradical and antioxidative effects. It can have positive effects on both the prevention of urolithiasis and possible inflammation during the existing urolithiasis and support the medical treatment. |
| Databáze: | OpenAIRE |
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