The double‐edged sword of Tregs in M tuberculosis , M avium , and M. abscessus infection

Autor:	Diane J. Ordway, Edward D. Chan, Deepshikha Verma
Rok vydání:	2021
Předmět:	0301 basic medicine Tuberculosis animal diseases Immunology chemical and pharmacologic phenomena Context (language use) Mycobacterium abscessus Article Microbiology Mycobacterium tuberculosis 03 medical and health sciences 0302 clinical medicine Immune system Immunity medicine Animals Humans Immunology and Allergy Lung biology biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification medicine.disease 030104 developmental biology medicine.anatomical_structure bacteria Mycobacterium avium 030215 immunology Mycobacterium
Zdroj:	Immunol Rev
ISSN:	1600-065X 0105-2896
DOI:	10.1111/imr.12959
Popis:	Immunity against different Mycobacteria species targeting the lung requires distinctly different pulmonary immune responses for bacterial clearance. Many parameters of acquired and regulatory immune responses differ quantitatively and qualitatively from immunity during infection with Mycobacteria species. Nontuberculosis Mycobacterial species (NTM) includes Mycobacterium avium- (M. avium), and Mycobacterium abscessus (M. abscessus). However, the more virulent Mycobacterial species by far are Mycobacterium tuberculosis-(Mtb). Herein, we discuss the potential implications of acquired and regulatory immune responses in the context of animal and human studies, as well as future directions for efforts to treat Mycobacteria diseases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81dcac7444ab820b04f9fbea1abba18 https://doi.org/10.1111/imr.12959 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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