Comparison of the effectiveness of a PAMG-1 test and standard clinical assessment in the prediction of preterm birth and reduction of unnecessary hospital admissions
| Autor: | Rasha M Abdeldayem, Raghunandini Koratkar, Ghassan Lotfi, Sreenisha Somini, Nadia Alsawalhi, Abeer Ammar, Saima Faraz, Razan Nasir |
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| Rok vydání: | 2017 |
| Předmět: |
Pediatrics
medicine.medical_specialty Preterm labor Medical Overuse Risk Assessment 03 medical and health sciences 0302 clinical medicine Obstetric Labor Premature Predictive Value of Tests Pregnancy Medicine Humans Prospective Studies Preterm delivery 030219 obstetrics & reproductive medicine business.industry 030503 health policy & services Obstetrics and Gynecology Gestational age Test (assessment) Insulin-Like Growth Factor Binding Protein 1 Pediatrics Perinatology and Child Health Biomarker (medicine) Observational study Female Cervical dilatation 0305 other medical science Risk assessment business |
| Zdroj: | The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 32(5) |
| ISSN: | 1476-4954 |
| Popis: | The purpose of this study is to first compare the performance of the PAMG-1 biomarker test to that of standard clinical assessment (SCA) for the risk assessment of spontaneous preterm delivery (sPTD) among women with symptoms of preterm labor (PTL) and then calculate the potential impact on unnecessary admission reduction.Patients of gestational age 24One hundred and forty-eight patients were included in the analysis, 132 of which had both SCA and PAMG-1 results available. For the prediction of sPTD ≤7 d for SCA and PAMG-1, the PPV and NPV were 10% and 100%, and 71% and 98%, respectively. For prediction of sPTD ≤14 d for SCA and PAMG-1, the PPV and NPV were 14% and 100%, and 86% and 96%, respectively. Sixty-one per cent (81/132) of patients were admitted for treatment and/or observation.Our study reinforces the critical role of the PAMG-1 biomarker test to aid in risk assessment of imminent spontaneous preterm delivery in patients with symptoms of PTL. The PAMG-1 test was found to be statistically superior to standard clinical assessment alone, with respect to specificity. Based on our data, the introduction of a PAMG-1 test result into clinical decision making could reduce up to 91% of unnecessary admissions for women presenting with threatened preterm labor. |
| Databáze: | OpenAIRE |
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