Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases

Autor:	Youngheun Jee, Hyung-Min Kim, Young-Gyun Shin, Changjong Moon, Meejung Ahn, Taekyun Shin, Chang-Sung Koh, Seungdam Heo, Seungjoon Kim, Ki-Bum Sim
Rok vydání:	2004
Předmět:	Male medicine.medical_specialty Encephalomyelitis Autoimmune Experimental Sodium Salicylate Encephalomyelitis Blotting Western Administration Oral Nitric Oxide Synthase Type II chemistry.chemical_compound Western blot Oral administration Internal medicine medicine Animals Cyclooxygenase Inhibitors Sodium salicylate biology medicine.diagnostic_test business.industry General Neuroscience Experimental autoimmune encephalomyelitis medicine.disease Immunohistochemistry Rats Myelin basic protein Nitric oxide synthase Endocrinology Spinal Cord chemistry Prostaglandin-Endoperoxide Synthases Rats Inbred Lew biology.protein Cyclooxygenase Nitric Oxide Synthase business
Zdroj:	Neuroscience Letters. 356:123-126
ISSN:	0304-3940
Popis:	We studied the effects of oral administration of sodium salicylate on the expression of the pro-inflammatory mediators, nitric oxide synthase (iNOS) and cyclooxygenase- (COX-) 1 and 2, in rats with experimental autoimmune encephalomyelitis (EAE). Sodium salicylate (200 mg/kg) was administered orally for 13 days after the induction of EAE by immunization with guinea pig myelin basic protein and complete Freund's adjuvant. The onset (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81a3f4708942dd97c2f3891ac25d173 https://doi.org/10.1016/j.neulet.2003.11.038 Zobrazit plný text záznamu Full Text from ScienceDirect