Decreased tissue stiffness in glioblastoma by MR elastography is associated with increased cerebral blood flow

Autor: Anna Latysheva, Jorunn Fraser-Green, Wibeke Nordhøy, Sverre Holm, Svensson Sf, Einar O. Vik-Mo, Kyrre E. Emblem, Hovden It, Elies Fuster-Garcia, Darwish Oi, Ralph Sinkus
Rok vydání: 2021
Předmět:
Zdroj: medRxiv
European Journal of Radiology
ISSN: 0720-048X
Popis: BACKGROUND: Understanding how mechanical properties relate to functional changes in glioblastomas may help explain variation between patients. PURPOSE: To map differences in biomechanical and functional properties between tumor and healthy tissue, to study their spatial distribution, and to assess any relationship between biomechanical and functional properties. STUDY TYPE: Prospective. SUBJECTS: Nine patients with glioblastoma, 17 healthy subjects FIELD STRENGTH/SEQUENCE: 3T, MRE, DSC, DTI, ASL ASSESSMENT: Stiffness and viscosity measurements G′ and G″, cerebral blood flow (CBF), apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured in patients′ contrast-enhancing tumor, necrosis, edema, and gray and white matter, and in gray and white matter for healthy subjects. STATISTICAL TESTS: Voxel-wise regression analysis using a linear and a random forest model for CBF as a function of ADC, FA, G′ and G″. Model performance was evaluated by root-mean-square error with a leave-one-patient-out cross-validation strategy. A paired Wilcoxon signed-rank test was used for comparisons of different regions and models. A significance level of P
Databáze: OpenAIRE