Role of Syntaxin 4 in Activity-Dependent Exocytosis and Synaptic Plasticity in Hippocampal Neurons
| Autor: | Muniesh Muthaiyan Shanmugam, Ponnuswamy Mohanasundaram |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Dendritic spine
Long-Term Potentiation Nonsynaptic plasticity AMPA receptor Hippocampus Biochemistry Exocytosis Membrane Microdomains Postsynaptic potential Animals Humans Receptors AMPA Molecular Biology Qa-SNARE Proteins Chemistry Long-term potentiation Munc-18 Dendrites Cell Biology Cell biology Protein Transport nervous system Synapses Synaptic plasticity SNARE Proteins Postsynaptic density |
| Zdroj: | Science Signaling. 3 |
| ISSN: | 1937-9145 1945-0877 |
| Popis: | Activity-dependent exocytosis of recycling endosomes that contain AMPA receptors in postsynaptic regions of hippocampal neurons occurs at microdomains enriched in the target SNARE [soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor] syntaxin 4 (Stx4). These Stx4-enriched domains are located near the postsynaptic density, and disrupting SNARE interactions involving Stx4 prevents the fusion of recycling endosomes that contain AMPA receptors in dendritic spines. AMPA receptor trafficking is important for long-term potentiation; thus, Stx4 is an essential postsynaptic component for synaptic plasticity in hippocampal neurons. |
| Databáze: | OpenAIRE |
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