Preventive effects of azathioprine (AZA) on the onset of diabetes mellitus in NOD mice
| Autor: | Filippo Calcinaro, M. L. Picchio, Paolo Brunetti, Alberto Falorni, M Pietropaolo, G. Basta, Riccardo Calafiore |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Azathioprine Islets of Langerhans Mice Endocrinology Mice Inbred NOD Internal medicine Cyclosporin a Diabetes mellitus medicine Animals Pancreas NOD mice Chemotherapy geography geography.geographical_feature_category business.industry Immunosuppression medicine.disease Islet Diabetes Mellitus Type 1 Cyclosporine Female business Insulitis medicine.drug |
| Popis: | We have studied the effects of long-term treatment with azathioprine (AZA) vs cyclosporin A (CSA) vs placebo (PL), in three groups of 10 week old, prediabetic NOD mice. One of 8 AZA, none of 8 CSA and 7 of 11 PL treated mice developed overt diabetes (IDDM). Quantitative morphometric analysis conducted on mouse pancreatic histologic sections documented that extent and degree of islet beta-cell damage were incomparably less severe in the mice that received AZA or CSA compared to those treated with PL. Since early and prolonged treatment with AZA seems to prevent the onset of DM in NOD mice as nearly effectively as CSA, AZA, which is significantly safer than CSA, could replace the latter as a potential approach for the immunotherapy of IDDM. |
| Databáze: | OpenAIRE |
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