The impact of successful learning of self-regulation on reward processing in children with ADHD using fMRI
| Autor: | Regina Boecker-Schlier, Isabella Wolf, Tobias Banaschewski, Nathalie E. Holz, Sarah Baumeister, Sarah Hohmann, Daniel Brandeis |
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| Přispěvatelé: | University of Zurich, Baumeister, Sarah |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Adolescent 610 Medicine & health Audiology Self-Control Reward processing 03 medical and health sciences 2738 Psychiatry and Mental Health 0302 clinical medicine Gyrus Reward medicine Humans Learning 0501 psychology and cognitive sciences 10064 Neuroscience Center Zurich Prefrontal cortex Child Functional Neuroimaging 05 social sciences Ventral striatum 3203 Clinical Psychology Brain Small sample General Medicine Neurophysiology Neurofeedback 10058 Department of Child and Adolescent Psychiatry Magnetic Resonance Imaging Psychiatry and Mental health Clinical Psychology Behavioral data medicine.anatomical_structure Attention Deficit Disorder with Hyperactivity 10076 Center for Integrative Human Physiology Female Psychology 030217 neurology & neurosurgery 050104 developmental & child psychology |
| DOI: | 10.5167/uzh-157001 |
| Popis: | Neurofeedback (NF) is a non-pharmacological treatment for attention-deficit/hyperactivity disorder (ADHD) that is targeting self-regulation, is efficacious when standard protocols are used and induces partly specific neurophysiological changes in the inhibitory network. However, its effects on reward processing, which is also considered an important aspect of ADHD and has been linked to neurophysiological deficits, remain unknown. Children with ADHD (N = 15, mean age 11.8, SD 1.52) were randomly assigned to either slow cortical potential NF (n = 8) or EMG biofeedback control training (n = 7) and received 20 sessions of training under comparable conditions. Learning was defined as the slope of successful training runs across all transfer sessions. Whole brain analysis, region-of-interest analysis of anticipatory ventral striatal (VS) activation, and analysis of behavioral data were performed. Clinically, the NF group improved more than the EMG group. Whole brain analysis indicated increased activation in the left superior frontal gyrus in the control group only, and in medial prefrontal cortex and dorsolateral prefrontal gyrus (DLPFC) after treatment across all groups. Only successful learners of self-regulation (n = 8) showed increased left inferior frontal gyrus and DLPFC activation after treatment. Left VS activation was increased after treatment and showed a significant time*medication-status interaction. Specific treatment effects were found in left frontal regions for the control treatment and successful learners. Also, unmedicated participants, irrespective of treatment type or successful learning, showed treatment-induced improvement in reward processing. The results suggest no prominent specific effect of NF on reward processing. However, cautious interpretation is warranted due to the small sample. |
| Databáze: | OpenAIRE |
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