Effect of fluoroquinolone on the enhanced nitric oxide-induced peripheral vasodilation seen in cirrhosis
| Autor: | Brindi Rasaratnam, Jaye Chin-Dusting, Francis J. Dudley, Garry L. Jennings |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Cirrhosis Vasodilation Nitric Oxide Nitric oxide chemistry.chemical_compound Anti-Infective Agents Double-Blind Method Liver Cirrhosis Alcoholic Internal medicine Blood plasma Internal Medicine medicine Humans Antibacterial agent Cross-Over Studies business.industry General Medicine Middle Aged medicine.disease Endotoxemia Forearm Blood pressure Endocrinology chemistry Regional Blood Flow Portal hypertension business Acetylcholine medicine.drug Norfloxacin |
| Zdroj: | Annals of internal medicine. 127(11) |
| ISSN: | 0003-4819 |
| Popis: | In patients with cirrhosis, portosystemic shunts allow intestinal bacteria and endotoxin to enter the systemic circulation. Endotoxemia may induce increased synthesis of nitric oxide, thereby contributing to arterial vasodilation.To test the hypothesis that the antibiotic norfloxacin blocks the effects of nitric oxide.Placebo-controlled, double-blind, crossover study.Alfred Hospital, Melbourne, Australia.9 patients with alcohol-related cirrhosis and 10 healthy controls.Norfloxacin, 400 mg twice daily, for 4 weeks.Peripheral blood flow was measured by using forearm venous occlusion plethysmography.Basal forearm blood flow was higher in patients with cirrhosis than in controls (3.69 +/- 0.27 mL/100 mL per minute and 2.47 +/- 0.40 mL/100 mL per minute; P = 0.014) but returned toward normal after norfloxacin was given (2.64 +/- 0.31 mL/100 mL of tissue per minute in patients with cirrhosis). Responses to NG-monomethyl-L-arginine were greater in patients with cirrhosis but returned to normal after norfloxacin was given.Bacterial endotoxemia in patients with cirrhosis induces increased synthesis of nitric oxide that can be corrected with norfloxacin. |
| Databáze: | OpenAIRE |
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