Red blood cell glutathione peroxidase activity in multiple sclerosis
| Autor: | Gromadzińska J, J. Czernicki, Chmielewski H, B. Zachara, Z. Maciejek |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythrocytes Multiple Sclerosis Internal medicine Drug Discovery medicine Humans Genetics (clinical) chemistry.chemical_classification Glutathione Peroxidase biology Chemistry Multiple sclerosis Glutathione peroxidase General Medicine Middle Aged Glutathione peroxidase activity medicine.disease Molecular medicine Enzyme assay Red blood cell medicine.anatomical_structure Endocrinology Immunology Etiology biology.protein Molecular Medicine Female |
| Zdroj: | Klinische Wochenschrift. 62:179-182 |
| ISSN: | 1432-1440 0023-2173 |
| DOI: | 10.1007/bf01731641 |
| Popis: | Glutathione peroxidase (GSH-Px) activity of red blood cells of 23 multiple sclerosis (MS) patients (10 men and 13 women, aged 22-64 years) was examined and compared to the enzyme activity of 26 healthy persons (15 men and 11 women, aged 19-50 years). It was found that the mean GSH-Px activity was significantly higher (P less than 0.001) in red blood cells of MS patients (39.1 +/- 8.1 IU/g Hb) as compared to the group of healthy persons (25.9 +/- 5.2 IU/g Hb). There was no difference according to sexes in both the MS patients and the control group. The results are discussed based on the hypothesis that organic peroxides play a role in the etiology of multiple sclerosis. |
| Databáze: | OpenAIRE |
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