Urinary hormonal profile during the first cycle of low-dose oral contraceptive pills in women
Autor: | Yousry Khamis, Hassan El Sokkary, Mahmoud Abou Ollo, Emad Darwish, Abdel Razek Souka |
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Rok vydání: | 1990 |
Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.drug_class Estrone media_common.quotation_subject Ovary Ethinyl Estradiol Oral administration Internal medicine medicine Endocrine system Humans Menstrual cycle media_common Genitourinary system business.industry Norgestrel Obstetrics and Gynecology Luteinizing Hormone Contraceptives Oral Combined Endocrinology medicine.anatomical_structure Reproductive Medicine Estrogen Pregnanediol Female business Luteinizing hormone Hormone |
Zdroj: | Contraception. 42(1) |
ISSN: | 0010-7824 |
Popis: | Ovarian function was studied in ten normal fertile women before and during the first cycle on a low-dose micropill containing 30 mcg ethinyl estradiol and 150 mcg L-norgestrel. In a control cycle and the first treatment cycle, steroid metabolites estrone-3-glucuronide (E1-3G) and pregnanediol-3α-glucuronide (Pd-3G) were measured in daily early morning urine (EMU) samples. Also, luteinizing hormone (LH) was estimated during the expected periovulatory period. During the first cycle of micropill intake, ovarian function was suppressed in all cases. This is evidenced by significantly lower E1-3G and Pd-3G and absent midcycle LH peak compared to control cycles. The pattern of steroid metabolites was almost flat with no peaks. It is concluded that there is no need to cover the first cycle of micropill intake with other contraceptive methods. |
Databáze: | OpenAIRE |
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