Exploration of supraspinal mechanisms in effects of spinal cord stimulation: Role of the locus coeruleus
| Autor: | Antti Pertovaara, Zhiyang Song, Bengt Linderoth, O.B. Ansah, Björn A. Meyerson |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Pain Threshold Action Potentials Periaqueductal gray Sciatica 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology Physical Stimulation Neural Pathways Animals Premovement neuronal activity Medicine Anesthetics Local Rats Wistar Neurons integumentary system business.industry General Neuroscience Imidazoles Lidocaine Prazosin Adrenergic alpha-2 Receptor Antagonists Nerve injury Spinal cord Electric Stimulation Rats Disease Models Animal medicine.anatomical_structure Spinal Cord nervous system Hyperalgesia Peripheral nerve injury Neuropathic pain Adrenergic alpha-1 Receptor Antagonists Locus coeruleus Locus Coeruleus Brainstem medicine.symptom business tissues Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience. 253:426-434 |
| ISSN: | 0306-4522 |
| Popis: | The neurobiological mechanisms of spinal cord stimulation (SCS) when applied for neuropathic pain are still incompletely known. Previous research indicates that brainstem circuitry is pivotal for the SCS effect. The present study aims at exploring the possible contribution to the SCS effects of the pain controlling system emanating from the locus coeruleus (LC) in the brain stem. Experiments were performed on the rat-spared nerve injury pain model. After evaluation of the attenuation of mechanical hypersensitivity induced by SCS, the effects of SCS on neuronal activity in the LC and on the noradrenaline (NA) content in the dorsal spinal cord were analyzed. SCS produced a significant increase in the discharge rate of LC neurons only in rats behaviorally responding to SCS as compared to non-responding and control animals. The NA content in the dorsal quadrant of the spinal cord ipsilateral to the nerve injury was analyzed using enzyme-linked immunosorbent assay in responding, non-responding and intact control rats both immediately following SCS and without SCS. No differences were found between these groups. In awake animals, lidocaine silencing of the ipsilateral LC or blocking of spinal noradrenergic system by intrathecal administration of α1,2 adrenoceptor antagonists failed to influence the antihypersensitivity effect of SCS. The present results indicate that the SCS-induced control of hypersensitivity in an experimental animal model of peripheral neuropathic pain may not be explained by the activation of direct spinal projections of noradrenergic LC neurons, while supraspinal projections of LC neurons still may play a role in the SCS effect. |
| Databáze: | OpenAIRE |
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