Effect of prolactin on glomerular filtration rate
| Autor: | A. L. Riley, T. C. Hagen, J. E. Stefaniak |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
medicine.medical_specialty Kidney Fractional excretion of sodium Dose-Response Relationship Drug urogenital system Chemistry Renal function Endogeny General Medicine Blood flow Prolactin Endocrinology medicine.anatomical_structure Dogs Internal medicine medicine Distribution (pharmacology) Animals Both kidneys Blood Flow Velocity Bromocriptine Glomerular Filtration Rate |
| Zdroj: | Clinical science and molecular medicine. 55(4) |
| ISSN: | 0301-0538 |
| Popis: | 1. The effect of infusion of ovine prolactin was studied in anaesthetized dogs pretreated with bromocryptine to reduce the release of endogenous prolactin. 2. Prolactin, injected intravenously and also directly into one kidney, resulted in a 12–18% increase in glomerular filtration rate (GFR) by both kidneys. 3. This increased GFR was not associated with any demonstrable changes in whole-kidney blood flow, distribution of intrarenal blood flow, fractional excretion of sodium or osmolar or free-water clearance. 4. We conclude that ovine prolactin produced an increase in GFR not dependent on an increase in whole-kidney plasma flow. |
| Databáze: | OpenAIRE |
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