The Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg)
| Autor: | Caldas M., Perez-Aisa A., Tepes B., Keco-Huerga A., Bujanda L., Lucendo A. J., Rodrigo L., Vaira D., Fernandez-Salazar L., Huguet J. M., Perez-Lasala J., Jurecic N. B., Fadeenko G., Barrio J., Areia M., Ortuno J., Pellicano R., Leja M., Molina-Infante J., Bogomolov P., Alekseenko S., Dominguez-Cajal M., Gomez-Camarero J., Ntouli V., Martinez-Dominguez S. J., Ruiz-Zorrilla R., Nunez O., Silkanovna Sarsenbaeva A., Almela P., Phull P., Espada M., Puig I., Nyssen O. P., Megraud F., O'Morain C., Gisbert J. P., the HP-EuReg Investigators, Gravina AG, Romano M. |
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| Přispěvatelé: | Caldas M., Perez-Aisa A., Tepes B., Keco-Huerga A., Bujanda L., Lucendo A.J., Rodrigo L., Vaira D., Fernandez-Salazar L., Huguet J.M., Perez-Lasala J., Jurecic N.B., Fadeenko G., Barrio J., Areia M., Ortuno J., Pellicano R., Leja M., Molina-Infante J., Bogomolov P., Alekseenko S., Dominguez-Cajal M., Gomez-Camarero J., Ntouli V., Martinez-Dominguez S.J., Ruiz-Zorrilla R., Nunez O., Silkanovna Sarsenbaeva A., Almela P., Phull P., Espada M., Puig I., Nyssen O.P., Megraud F., O'Morain C., Gisbert J.P., Caldas, M., Perez-Aisa, A., Tepes, B., Keco-Huerga, A., Bujanda, L., Lucendo, A. J., Rodrigo, L., Vaira, D., Fernandez-Salazar, L., Huguet, J. M., Perez-Lasala, J., Jurecic, N. B., Fadeenko, G., Barrio, J., Areia, M., Ortuno, J., Pellicano, R., Leja, M., Molina-Infante, J., Bogomolov, P., Alekseenko, S., Dominguez-Cajal, M., Gomez-Camarero, J., Ntouli, V., Martinez-Dominguez, S. J., Ruiz-Zorrilla, R., Nunez, O., Silkanovna Sarsenbaeva, A., Almela, P., Phull, P., Espada, M., Puig, I., Nyssen, O. P., Megraud, F., O'Morain, C., Gisbert, J. P., the HP-EuReg, Investigator, Gravina, Ag, Romano, M. |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Multivariate analysis Helicobacter pylori statins treatment RM1-950 Biochemistry Microbiology Article statins Rescue therapy Internal medicine In real life Medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Helicobacter pylori treatment biology business.industry Statin Statin treatment biology.organism_classification Treatment Infectious Diseases Therapeutics. Pharmacology business |
| Zdroj: | ANTIBIOTICS-BASEL r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname Antibiotics Volume 10 Issue 8 Zaguán. Repositorio Digital de la Universidad de Zaragoza Antibiotics, Vol 10, Iss 965, p 965 (2021) |
| ISSN: | 2079-6382 |
| Popis: | Statins could increase the effectiveness of Helicobacter pylori eradication therapies due to their anti-inflammatory effect. The aim of this study was to analyze the impact of this therapeutic association in real life. This is a multicenter, prospective, non-interventional study aimed at evaluating the management of H. pylori by European gastroenterologists. Patients were registered in an e-CRF by AEG-REDCap from 2013 to 2020. The association between statin use and H. pylori eradication effectiveness was evaluated through multivariate analysis. Overall, 9988 and 705 patients received empirical and culture-guided treatment, respectively. Overall, statin use was associated with higher effectiveness in the empirical group (OR = 1.3 95%CI = 1.1–1.5), but no association was found with first-line treatment effectiveness (N = 7738) as an exception, statin use was specifically associated with lower effectiveness of standard triple therapy (OR = 0.76 95%CI = 0.59–0.99). In the rescue therapy empirical group (N = 2228), statins were associated with higher overall effectiveness (OR = 1.9 95%CI = 1.4–2.6). However, sub-analyses by treatment schemes only confirmed this association for the single-capsule bismuth quadruple therapy (OR = 2.8 95%CI = 1.3–5.7). No consistent association was found between statin use and H. pylori therapy effectiveness. Therefore, the addition of statins to the usual H. pylori treatment cannot be currently recommended to improve cure rates. |
| Databáze: | OpenAIRE |
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