Neurotoxic tau oligomers after single versus repetitive mild traumatic brain injury
| Autor: | Mauro Montalbano, Rakez Kayed, Charles L. Rosen, Brandon Lucke-Wold, Tasneem F. Hasan, Nicha Puangmalai, Alice Bittar, Giulio Taglialatela, Mariana Carretero Murillo, Nemil Bhatt, Ryan C. Turner, Salome McAllen, Aric F. Logsdon, Anna Ellsworth |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
tau oligomers Pathology medicine.medical_specialty Traumatic brain injury Tau protein 03 medical and health sciences 0302 clinical medicine mental disorders medicine tau strains Dementia Nerve degeneration biology business.industry tau polymorphisms traumatic brain injury Neurodegeneration General Engineering neurodegeneration Long-term potentiation medicine.disease 030104 developmental biology Toxicity biology.protein Original Article business 030217 neurology & neurosurgery |
| Zdroj: | Brain Communications |
| ISSN: | 2632-1297 |
| Popis: | Soluble tau aggregates have been highlighted in mTBI-induced cellular dysfunction and neurodegeneration. We used an established mTBI model to investigate differences between tau oligomers isolated after single vs. repetitive mTBI. Single and repeated blast tau oligomers expressed distinct strain-indicating characteristics that correlated with the risk of neurodegeneration. Mild traumatic brain injury accounts for the majority of head injuries and has been correlated with neurodegeneration and dementia. While repetitive mild traumatic brain injury is highly correlated to neurodegeneration, the correlation of a single mild traumatic brain injury with neurodegeneration is still unclear. Because tau aggregates are the main form of mild traumatic brain injury induced pathology, toxic forms of tau protein most likely play a role in the development of post-mild traumatic brain injury neurodegeneration. Therefore, it becomes crucial to characterize the properties of soluble tau aggregates in single versus repetitive mild traumatic brain injury. Herein, we isolated tau oligomers from wild-type mice exposed to single or repetitive mild traumatic brain injury and characterized the tau aggregates at functional, biochemical and biophysical levels. We demonstrated that single versus repetitive mild traumatic brain injuries frequencies lead to the formation of different tau oligomeric polymorphisms. These polymorphisms express different long-term potentiation impairment potencies, toxicity potentials, morphologies and strain indicating properties. To our knowledge, this is the first evidence that soluble tau oligomers derived from single versus repetitive mild traumatic brain injuries form distinct polymorphisms that possibly correlate with the risk of neurodegeneration after mild traumatic brain injury. Graphical Abstract Graphical Abstract |
| Databáze: | OpenAIRE |
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