Establishment and characterization of T-cell lines (yana-I and yana-II) derived from a patient with chronic adult T-cell leukemia (ATL)
| Autor: | Yasuji Amano, Akira B. Miura, Ikuo Miura, Akihiko Yamaguchi |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Genetic Markers
T-Lymphocytes Marker chromosome T cell T-cell leukemia Antibodies Viral Deltaretrovirus Peripheral blood mononuclear cell General Biochemistry Genetics and Molecular Biology Cell Line Retrovirus immune system diseases hemic and lymphatic diseases medicine Humans biology General Medicine Middle Aged biology.organism_classification medicine.disease Molecular biology Leukemia Lymphoid Lymphoma Retroviridae medicine.anatomical_structure Cell culture Karyotyping biology.protein Female Antibody |
| Zdroj: | The Tohoku Journal of Experimental Medicine. 152:139-149 |
| ISSN: | 1349-3329 0040-8727 |
| DOI: | 10.1620/tjem.152.139 |
| Popis: | ATL-cell lines producing C-type retroviruses were established by culture of the peripheral blood mononuclear cells from a patient with chronic ATL. These cell lines had the surface feature of inducer/helper T-cells with electron microscopic finding of C-type retrovirus on the cell surface. Chromosome analysis revealed the presence of a marker chromosome, but did not identify 7 trisomy nor 14q+. Of the cell lines, the line established by culture with TCGF was named "Yana-I" and the line established by culture of Yana-I without adding TCGF was named "Yana-II". Serum ATLA-antibody was positive in 1.5% of the healty individuals examined (4/257). Among malignant lymphoma patients, ATLA antibody was positive in none of the patients with B-cell type lymphoma (0/10) and Hodgkin's disease (0/2). In contrast, ATLA antibody was found in half of the patients with T-cell type lymphoma (3/6) and all with ATL (4/4). This suggested that C-type retrovirus in closely associated with ATLL. |
| Databáze: | OpenAIRE |
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