In-vitro activity of S. lavandulaefolia (Spanish sage) relevant to treatment of Alzheimer's disease
| Autor: | M. Lis-Balchin, J.Robin S. Hoult, Anthony E. Theobald, Nicolette S. L. Perry, Peter J. Houghton, Stuart Milligan, Julia Sampson, Elaine K. Perry, Peter Jenner, Patricia Evans, Stephen L. Hart |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Antioxidant
medicine.medical_treatment Pharmaceutical Science Phytoestrogens Saccharomyces cerevisiae In Vitro Techniques Pharmacology Antioxidants law.invention Camphor chemistry.chemical_compound Alzheimer Disease law Oils Volatile medicine Animals Humans Estrogens Non-Steroidal Salvia Thujone Cells Cultured Essential oil chemistry.chemical_classification SAGE Anti-Inflammatory Agents Non-Steroidal Isoflavones Acetylcholinesterase Enzyme Receptors Estrogen chemistry Eicosanoids Cattle Lipid Peroxidation Plant Preparations Geraniol Phytotherapy |
| Zdroj: | Journal of Pharmacy and Pharmacology. 53:1347-1356 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1211/0022357011777846 |
| Popis: | Salvia lavandulaefolia Vahl. (Spanish sage) essential oil and individual monoterpenoid constituents have been shown to inhibit the enzyme acetylcholinesterase in-vitro and in-vivo. This activity is relevant to the treatment of Alzheimer's disease, since anticholinesterase drugs are currently the only drugs available to treat Alzheimer's disease. Other activities relevant to Alzheimer's disease include antioxidant, anti-inflammatory and estrogenic effects. Results of in-vitro tests for these activities are reported here for S. lavandulaefolia extracts, the essential oil and its major constituents. Antioxidant activity (inhibition of bovine brain liposome peroxidation) was found in the EtOH extract of the dried herb (5 mg mL−1) and the monoterpenoids (0.1 M) α- and β-pinene and 1,8-cineole. Thujone and geraniol had lower antioxidant effects, while camphor had no antioxidant effects. Possible anti-inflammatory activity (eicosanoid inhibition in rat leucocytes) was found in the EtOH extract (50 μg mL−1) and was shown by the monoterpenoids α-pinene and geraniol (0.2 mM), but not 1,8-cineole, thujone or camphor. Possible estrogenic activity (via induction of β-galactosidase activity in yeast cells) was found in the essential oil (0.01 mg mL−1) and the monoterpenoid geraniol (0.1–2 mM). 1,8-Cineole, α- and β-pinene and thujone did not exhibit estrogenic activity in this analysis. These results demonstrate that S. lavandulaefolia, its essential oil and some chemical constituents have properties relevant to the treatment of Alzheimer's disease and provide further data supporting the value of carrying out clinical studies in patients with Alzheimer's disease using this plant species. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text