Response of guanylate cyclase to atrial natriuretic factor in epithelial cells of the frog choroid plexus
| Autor: | B. Santarella, C. Roscani, Farnesi Rm, T. Secca, Simonetta Tei, Daniela Vagnetti |
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| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Liquid composition Biology Epithelium Rana Basal (phylogenetics) Internal medicine medicine Animals Cyclic GMP chemistry.chemical_classification Histocytochemistry Cell Polarity Rana esculenta Epithelial Cells Cell Biology General Medicine Cell biology Enzyme Endocrinology chemistry Guanylate Cyclase Choroid Plexus Choroid plexus Intracellular Atrial Natriuretic Factor Developmental Biology Hormone Guanylate cyclase Signal Transduction |
| Popis: | This study shows that the choroid plexus of Rana esculenta contains a guanylate cyclase particulate (GCp), similar to that identified in Mammalia, that is quite sensitive to the atrial natriuretic factor (ANF). The cytochemical tests for GCp show that ANF increases the enzymatic reaction products. Deposits are observed on the apical portion, at the basal level and along the lateral edges of the epithelial cells, with the exclusion of some intercalary epithelial cells with reaction-lacking microvilli. In particular, ANF seems to intensely stimulate the GCp activity along the lateral membranes of the epithelial cells delimiting enlarged intercellular spaces, which are probably dilated for the transport of water and solutes. These data confirm the osmoregulatory role of the hormone and its control of cephalorachidian liquid composition. |
| Databáze: | OpenAIRE |
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