Reduced plasma Fetuin-A is a promising biomarker of depression in the elderly
| Autor: | Ashwin A. Patkar, Changsu Han, Prakash S. Masand, Sheng Min Wang, Chiara Fabbri, Tae Youn Jun, Giuseppe Fanelli, Francesco Benedetti, Chi-Un Pae, Soo-Jung Lee, Alessandro Serretti |
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| Přispěvatelé: | Fanelli G., Benedetti F., Wang S.-M., Lee S.-J., Jun T.-Y., Masand P.S., Patkar A.A., Han C., Serretti A., Pae C.-U., Fabbri C., Fanelli, G., Benedetti, F., Wang, S. -M., Lee, S. -J., Jun, T. -Y., Masand, P. S., Patkar, A. A., Han, C., Serretti, A., Pae, C. -U., Fabbri, C. |
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Male medicine.medical_specialty Aging alpha-2-HS-Glycoprotein Disease Severity of Illness Index 03 medical and health sciences Elderly 0302 clinical medicine Neuroinflammation Internal medicine medicine Major depression Humans Pharmacology (medical) Prospective Studies Biological Psychiatry Depression (differential diagnoses) Aged Aged 80 and over Depressive Disorder Major business.industry Confounding Biomarker General Medicine Middle Aged medicine.disease Blood proteins Fetuin-A 030227 psychiatry Peripheral Prolactin Psychiatry and Mental health Major depressive disorder Biomarker (medicine) Geriatric Depression Scale Female business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | European archives of psychiatry and clinical neuroscience. 270(7) |
| ISSN: | 1433-8491 |
| Popis: | Depression affects 7% of the elderly population, and it often remains misdiagnosed or untreated. Peripheral biomarkers might aid clinicians by allowing more accurate and well-timed recognition of the disease. We sought to determine if plasma protein levels predict the severity of depressive symptomatology or distinguish patients from healthy individuals. The severity of depressive symptoms and global cognitive functioning were assessed by the Geriatric Depression Scale (GDS) and Mini-Mental State Examination (MMSE) in 152 elderly subjects, 76 of which with major depressive disorder (MDD). Plasma levels of 24 proteins were measured by multiplexing and analyzed as continuous predictors or dichotomized using the median value. The association between individual plasma proteins and MDD risk or depressive symptoms severity was investigated using multiple logistic and linear regressions including relevant covariates. Sensitivity analyses were performed excluding cognitively impaired individuals or non-acute patients with MDD. After adjusting for possible confounders and false discovery rate (FDR) correction, we found lower Fetuin-A levels in MDD patients vs. controls (pFDR = 1.95 × 10–6). This result was confirmed by the sensitivity and dichotomized analyses. Lower prolactin (PRL) levels predicted more severe depressive symptoms in acute MDD patients (pFDR = 0.024). Fetuin-A is a promising biomarker of MDD in the elderly as this protein was negatively associated with the disorder in our sample, regardless of the global cognitive functioning. Lower PRL levels may be a peripheral signature of impaired neuroprotective processes and serotoninergic neurotransmission in more severely depressed patients. |
| Databáze: | OpenAIRE |
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