Sex specific trajectories of central adiposity, lipid indices, and glucose level with incident hypertension: 12 years Follow-up in Tehran lipid and glucose study
| Autor: | Davood Khalili, Seyed Saeed Tamehri Zadeh, Fereidoun Azizi, Noushin Sadat Ahanchi, Farzad Hadaegh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate statistics Waist Trajectory lcsh:Medicine 030204 cardiovascular system & hematology Iran Gastroenterology Triglyceride General Biochemistry Genetics and Molecular Biology Body Mass Index 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Risk Factors Internal medicine medicine Humans 030212 general & internal medicine Triglycerides Adiposity business.industry Cholesterol Research lcsh:R Hazard ratio General Medicine Sex specific Lipids Glucose chemistry Cohort Hypertension Waist circumference Female business Follow-Up Studies |
| Zdroj: | Journal of Translational Medicine Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-12 (2021) |
| ISSN: | 1479-5876 |
| Popis: | AimsTo identify sex specific trajectories of waist circumference (WC),triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and fasting plasma glucose (FPG) during adulthood and examine their associations with incident hypertension.MethodsThe cohort consisted of 5030 participants (2051 males) with at least 2 repeated measurement during a median of 12 years follow up. We identified trajectory groups using latent class growth mixture model, their association with hypertension was examined using multivariate Cox-regression analysis.ResultsWe found 997 cases of hypertension (483 male). For both exposures, three distinct trajectory groups were identified in both genders. For WC, in women: low-increasing, 82.4%; high-stable, 13.4%; high-increasing, 4.2% and in men: stable, 94.6%; low-increasing, 3.6% and for high- increasing, 1.7%. For TG, in women: stable, 91.3%; decreasing, 5.9%; inverse U-shape, 2.8%; in men: stable, 89.7%; inverse U- shape, 6.2% and for decreasing, 4.1%.Regarding WC, high stable and high-increasing trajectories were associated with hypertension in the multivariate model [(hazard ratio (HR) = 1.66 (95% CI 1.26–2.20) and 2.78(1.79–3.60), respectively]. Among men, this association was shown only for the low-increasing trajectory [2.76: 1.49–5.10]. For TG, among women decreasing and inverse U-shape trajectories were significantly associated with hypertension in the multivariate model [1.32:1.01–1.76] and [2.23:1.58–3.23, respectively].We did not find any impact of increasing trajectories of FPG and HDL-C on incident hypertension. Considering TC, all individuals followed a stable trajectory.ConclusionWC dynamic changes in both gender and TG trajectory among women were significantly associated with incident hypertension. |
| Databáze: | OpenAIRE |
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