A study of residual lesions in horses that recovered from clinical signs of chronic equine dysautonomia

Autor: Caroline Hahn, R. Scott Pirie, D. Drummond, Elspeth Milne, Bruce McGorum, Sharon Moss, Jorge Del-Pozo
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Pathology
intestinal motility
dysautonomia
interstitial cells of Cajal
Standard Article
030204 cardiovascular system & hematology
Enteric Nervous System
Muscle hypertrophy
0403 veterinary science
Amyloid beta-Protein Precursor
0302 clinical medicine
Prospective Studies
Myenteric plexus
Neurons
lcsh:Veterinary medicine
04 agricultural and veterinary sciences
Standard Articles
Ganglion
horse
Intestines
Proto-Oncogene Proteins c-kit
medicine.anatomical_structure
Neurology
c‐kit
Disease Progression
symbols
Immunohistochemistry
medicine.symptom
medicine.medical_specialty
040301 veterinary sciences
Ileum
Primary Dysautonomias
03 medical and health sciences
symbols.namesake
PGP 9.5
grass sickness
ubiquitin
medicine
Animals
Horses
General Veterinary
business.industry
Proteins
Dysautonomia
Interstitial cell of Cajal
Case-Control Studies
Cervical ganglia
BAPP
lcsh:SF600-1100
Horse Diseases
EQUID
business
Biomarkers
Zdroj: Journal of Veterinary Internal Medicine, Vol 33, Iss 5, Pp 2302-2311 (2019)
Journal of Veterinary Internal Medicine
Milne, E, Pirie, R, Hahn, C, Del-Pozo, J, Drummond, D, Moss, S & McGorum, B 2019, ' A study of residual lesions in horses that recovered from clinical signs of chronic equine dysautonomia ', Journal of Veterinary Internal Medicine . https://doi.org/10.1111/jvim.15567
ISSN: 0891-6640
1939-1676
DOI: 10.1111/jvim.15567
Popis: Background Equine dysautonomia (ED) causes degeneration and loss of autonomic neurons. Approximately 50% of chronic cases recover, but it is unclear how they survive neuronal loss. Objectives To assess lesions, autonomic neuron numbers, interstitial cells of Cajal (ICC), and neurodegeneration in recovered cases. Animals Thirteen cases (group ED), euthanized 10.3 ± 5.2 (1–16) years from diagnosis and 6 age‐matched controls (group C). Methods Prospective, case control; routine post mortem examination, neuron counts in peripheral and enteric ganglia and immunohistochemical assessment of neural networks (Protein gene product [PGP] 9.5), ICC (c‐kit), and neurodegeneration (beta‐amyloid precursor protein and ubiquitin) in intestine. Results Postmortem findings in group ED were small intestinal dilation (4/12, 33%) and muscular hypertrophy (4/12, 33%), and gastric mucosal hypertrophy (3/11, 27%) and ulceration (4/11, 36%). Neuron density was lower in group ED (mean 39% lower for cranial cervical ganglion [P
Databáze: OpenAIRE
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