Insight Into Myocardial Microstructure of Athletes and Hypertrophic Cardiomyopathy Patients Using Diffusion Tensor Imaging

Autor: Christian T. Stoeck, Jürgen E. Schneider, Erica Dall’Armellina, Louise A.E. Brown, Amrit Chowdhary, Irvin Teh, Nicholas Jex, Anshuman Sengupta, H Ben-Arzi, Peter P Swoboda, Stephen P. Page, Arka Das, John P Greenwood, Sven Plein, Thomas P. Craven, Nicholas Maxwell, Sebastian Kozerke, Christopher E.D. Saunderson, C Kelly
Přispěvatelé: University of Zurich, Dall'Armellina, Erica
Rok vydání: 2020
Předmět:
medicine.medical_specialty
Population
610 Medicine & health
030218 nuclear medicine & medical imaging
Sudden cardiac death
170 Ethics
hypertrophic cardiomyopathy
athlete's heart
diffusion tensor imaging
magnetic resonance imaging
03 medical and health sciences
0302 clinical medicine
Internal medicine
Fractional anisotropy
medicine
2741 Radiology
Nuclear Medicine and Imaging
Humans
10237 Institute of Biomedical Engineering
Radiology
Nuclear Medicine and imaging
Prospective Studies
education
Prospective cohort study
education.field_of_study
biology
medicine.diagnostic_test
Athletes
business.industry
Myocardium
Hypertrophic cardiomyopathy
Magnetic resonance imaging
Cardiomyopathy
Hypertrophic
biology.organism_classification
medicine.disease
3. Good health
Diffusion Tensor Imaging
Radiology Nuclear Medicine and imaging
Cardiology
business
Diffusion MRI
Zdroj: Journal of Magnetic Resonance Imaging, 53 (1)
ISSN: 1522-2586
1053-1807
Popis: Background Hypertrophic cardiomyopathy (HCM) remains the commonest cause of sudden cardiac death among young athletes. Differentiating between physiologically adaptive left ventricular (LV) hypertrophy observed in athletes' hearts and pathological HCM remains challenging. By quantifying the diffusion of water molecules, diffusion tensor imaging (DTI) MRI allows voxelwise characterization of myocardial microstructure. Purpose To explore microstructural differences between healthy volunteers, athletes, and HCM patients using DTI. Study Type Prospective cohort. Population Twenty healthy volunteers, 20 athletes, and 20 HCM patients. Field Strength/Sequence 3T/DTI spin echo. Assessment In‐house MatLab software was used to derive mean diffusivity (MD) and fractional anisotropy (FA) as markers of amplitude and anisotropy of the diffusion of water molecules, and secondary eigenvector angles (E2A)—reflecting the orientations of laminar sheetlets. Statistical Tests Independent samples t‐tests were used to detect statistical significance between any two cohorts. Analysis of variance was utilized for detecting the statistical difference between the three cohorts. Statistical tests were two‐tailed. A result was considered statistically significant at P ≤ 0.05. Results DTI markers were significantly different between HCM, athletes, and volunteers. HCM patients had significantly higher global MD and E2A, and significantly lower FA than athletes and volunteers. (MDHCM = 1.52 ± 0.06 × 10−3 mm2/s, MDAthletes = 1.49 ± 0.03 × 10−3 mm2/s, MDvolunteers = 1.47 ± 0.02 × 10−3 mm2/s, P
Databáze: OpenAIRE
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