The External Genitalia Score (EGS): A European Multicenter Validation Study
| Autor: | Katja Kp Wolffenbuttel, Olaf Hiort, Martine Cools, Anna Nordenström, Sabine Se Hannema, Marie Lindhardt Ljubicic, Ursula Tonnhofer, Stefanie Graf, Małgorzata Baumert, Christa E. Flück, Jon Sigurdsson, Aneta Gawlik, Alexander S Busch, An Desloovere, Malgorzata Wasniewska, Domenico Corica, Saskia van der Straaten, S Faisal Ahmed, Koenraad Smets, Sara Debulpaep, Mariarosa Calafiore, Aleksandra Zecic, Tanja Haamberg, Doris Hebenstreit, Kamila Szeliga, Alexander Springer, Anders Juul, Lloyd J.W. Tack |
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| Přispěvatelé: | Pediatric surgery, Pediatrics, Urology |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Intraclass correlation Endocrinology Diabetes and Metabolism Clinical Biochemistry Atypical Genitalia Disorders of Sex Development Biochemistry 0302 clinical medicine Endocrinology Reference Values Medicine 030212 general & internal medicine 610 Medicine & health Obstetrics atypical genitalia Genitalia Female/anatomy & histology Micropenis Genitalia Female Europe external masculinization score Gestation Female Radiology Infant Premature Genitalia Male/anatomy & histology medicine.medical_specialty Validation study 030209 endocrinology & metabolism Context (language use) Gestational Age Genitalia Male 03 medical and health sciences Internal medicine Disorders of Sex Development/diagnosis Humans business.industry Biochemistry (medical) Significant difference external genitalia score Infant Newborn Reproducibility of Results anogenital distances medicine.disease Cross-Sectional Studies anogenital distances atypical genitalia external genitalia score external masculinization score External genitalia 570 Life sciences biology business |
| Zdroj: | Journal of Clinical Endocrinology and Metabolism, 105(3):dgz142. The Endocrine Society Van Der Straaten, S, Springer, A, Zecic, A, Hebenstreit, D, Tonnhofer, U, Gawlik, A, Baumert, M, Szeliga, K, Debulpaep, S, Desloovere, A, Tack, L, Smets, K, Wasniewska, M, Corica, D, Calafiore, M, Ljubicic, M L, Busch, A S, Juul, A, Nordenström, A, Sigurdsson, J, Flück, C E, Haamberg, T, Graf, S, Hannema, S E, Wolffenbuttel, K P, Hiort, O, Ahmed, S F & Cools, M 2020, ' The External Genitalia Score (EGS) : A European Multicenter Validation Study ', Journal of Clinical Endocrinology and Metabolism, vol. 105, no. 3, dgz142 . https://doi.org/10.1210/clinem/dgz142 Journal of Clinical Endocrinology and Metabolism, 105. Endocrine Society van der Straaten, S, Springer, A, Zecic, A, Hebenstreit, D, Tonnhofer, U, Gawlik, A, Baumert, M, Szeliga, K, Debulpaep, S, Desloovere, A, Tack, L, Smets, K, Wasniewska, M, Corica, D, Calafiore, M, Ljubicic, M L, Busch, A S, Juul, A, Nordenström, A, Sigurdsson, J, Flück, C E, Haamberg, T, Graf, S, Hannema, S E, Wolffenbuttel, K P, Hiort, O, Ahmed, S F & Cools, M 2020, ' The External Genitalia Score (EGS) : A European Multicenter Validation Study ', Journal of Clinical Endocrinology and Metabolism, vol. 105, no. 3, pp. e222–e230 . https://doi.org/10.1210/clinem/dgz142 van der Straaten, Saskia; Springer, Alexander; Zecic, Aleksandra; Hebenstreit, Doris; Tonnhofer, Ursula; Gawlik, Aneta; Baumert, Malgorzata; Szeliga, Kamila; Debulpaep, Sara; Desloovere, An; Tack, Lloyd; Smets, Koen; Wasniewska, Malgorzata; Corica, Domenico; Calafiore, Mariarosa; Ljubicic, Marie Lindhardt; Busch, Alexander Siegfried; Juul, Anders; Nordenström, Anna; Sigurdsson, Jon; ... (2020). The External Genitalia Score (EGS): A European multicenter validation study. The journal of clinical endocrinology and metabolism, 105(3) Oxford University Press 10.1210/clinem/dgz142 |
| ISSN: | 0021-972X |
| Popis: | Context Standardized description of external genitalia is needed in the assessment of children with atypical genitalia. Objectives To validate the External Genitalia Score (EGS), to present reference values for preterm and term babies up to 24 months and correlate obtained scores with anogenital distances (AGDs). Design, Setting A European multicenter (n = 8) validation study was conducted from July 2016 to July 2018. Patients and Methods EGS is based on the external masculinization score but uses a gradual scale from female to male (range, 0–12) and terminology appropriate for both sexes. The reliability of EGS and AGDs was determined by the interclass correlation coefficient (ICC). Cross-sectional data were obtained in 686 term babies (0–24 months) and 181 preterm babies, and 111 babies with atypical genitalia. Results The ICC of EGS in typical and atypical genitalia is excellent and good, respectively. Median EGS (10th to 90th centile) in males < 28 weeks gestation is 10 (8.6–11.5); in males 28–32 weeks 11.5 (9.2–12); in males 33–36 weeks 11.5 (10.5–12) and in full-term males 12 (10.5–12). In all female babies, EGS is 0 (0-0). The mean (SD) lower/upper AGD ratio (AGDl/u) is 0.45 (0.1), with significant difference between AGDl/u in males 0.49 (0.1) and females 0.39 (0.1) and intermediate values in differences of sex development (DSDs) 0.43 (0.1). The AGDl/u correlates with EGS in males with typical genitalia and in atypical genitalia. Conclusions EGS is a reliable and valid tool to describe external genitalia in premature and term babies up to 24 months. EGS correlates with AGDl/u in males. It facilitates standardized assessment, clinical decision-making and multicenter research. |
| Databáze: | OpenAIRE |
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