Treatment of keloids and hypertrophic scars with dermojet injections of bleomycin: a preliminary study
| Autor: | Yasemin Saray, A. Tülin Güleç |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Triamcinolone acetonide Erythema Adolescent Cicatrix Hypertrophic medicine.medical_treatment Pain Dermatology Injections Intralesional Bleomycin Muscle hypertrophy Lesion chemistry.chemical_compound Hyperpigmentation medicine Humans Aged Pliability Chemotherapy Antibiotics Antineoplastic business.industry Middle Aged Surgery Treatment Outcome chemistry Keloid Female medicine.symptom business medicine.drug Follow-Up Studies |
| Zdroj: | International journal of dermatology. 44(9) |
| ISSN: | 0011-9059 |
| Popis: | Background Numerous treatment modalities have been used to treat keloids and hypertrophic scars, but the optimal treatment has not been established. Objective The aim of this study was to determine the efficacy and safety of intralesional jet injection of bleomycin as therapy for keloids and hypertrophic scars that are unresponsive to intralesional steroid injection. Methods The study included 14 patients with 15 keloids or hypertrophic scars that had not responded to a minimum of three intralesional injections of triamcinolone acetonide. Multiple jet injections of 0.1 ml of bleomycin (1.5 IU/ml) were administered to each lesion, with injection sites spaced 0.5 mm apart. Injections were repeated each month. Scar height was measured, and scar pliability and erythema were scored at baseline and then monthly during the treatment and follow-up periods. Patients’ self-assessments of subjective symptoms (pruritus and pain) were also scored. Clinical improvement was defined primarily on the basis of scar height reduction (percentage reduction from baseline), and was classified using the following scale: complete flattening (100%), highly significant flattening (> 90%), significant flattening (75–90%), moderate flattening (50–75%), and minimal flattening ( |
| Databáze: | OpenAIRE |
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