PERINATAL NUTRITION ENRICHED WITH OMEGA-3 POLYUNSATURATED FATTY ACIDS ATTENUATES ENDOTOXIC SHOCK IN NEWBORN RATS
| Autor: | M. Goto, W. P. Zeller, Thomas F. Myers, Craig L. Anderson, L. R. Farolan |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Lipopolysaccharide medicine.medical_treatment Intraperitoneal injection Hypoglycemia Critical Care and Intensive Care Medicine Dinoprostone Rats Sprague-Dawley Sepsis chemistry.chemical_compound Dietary Fats Unsaturated Pregnancy Fatty Acids Omega-6 Internal medicine Fatty Acids Omega-3 medicine Animals Lactic Acid chemistry.chemical_classification business.industry Septic shock Blotting Northern medicine.disease Shock Septic Rats Endocrinology Animals Newborn Liver chemistry Biochemistry Gluconeogenesis Shock (circulatory) Fatty Acids Unsaturated Emergency Medicine Eicosanoids Pregnancy Animal Animal Nutritional Physiological Phenomena Female Phosphoenolpyruvate Carboxykinase (GTP) medicine.symptom business Polyunsaturated fatty acid |
| Zdroj: | Shock. 6:263-266 |
| ISSN: | 1073-2322 |
| DOI: | 10.1097/00024382-199610000-00007 |
| Popis: | Sepsis and septic shock continue to have a high mortality and morbidity in the newborn. Eicosanoids are important mediators in Gram negative septic shock. Omega-3 polyunsaturated fatty acids (omega-3) decrease production of biologically active 2-series eicosanoids. Therefore, we hypothesized that omega-3-enriched diet could decrease 2-series eicosanoids and attenuate endotoxic shock in newborn rats. Sprague-Dawley rat dams were fed with either omega-3 polyunsaturated fatty acid-enriched diet (omega-3 PURA) or omega-6 polyunsaturated fatty acid enriched diet (omega-6PUFA; controls) from the 16th day of gestation until 10 days after parturition. In 10 day old rats, shock was induced by an intraperitoneal injection of Salmonella enteritidis lipopolysaccharide. The omega-3PUFA decreased the mortality of endotoxic shock. In omega-6PUFA, lipopolysaccharide induced hyperglycemia at 2 h and hypoglycemia thereafter without an elevation in plasma insulin concentration, omega-3PUFA attenuated the hyperglycemia and hypoglycemia. omega-3PUFA attenuated the decrease of liver phosphoenolpyruvate ca-boxykinase mRNA abundance, suggesting preserved gluconeogenesis. Therefore, perinatal feeding with omega-3PUFA was beneficial in attenuating glucose dyshomeostasis in newborn rats with endotoxic shock and may be a novel approach to the prevention of endotoxic shock in the newborn. |
| Databáze: | OpenAIRE |
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