Dystrophic neurites infiltrate extracellular neurofibrillary tangles in Alzheimer disease
| Autor: | Mitsuru Kawai, George Perry, Sandra L. Siedlak, Patrick Cras, Jennifer Vande Weghe, Massimo Tabaton, Barry D. Greenberg |
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| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: |
Aged
Alzheimer Disease pathology Amyloid beta-Peptides metabolism Extracellular Space Humans Neurites metabolism/ultrastructure Neurofibrillary Tangles pathology tau Proteins metabolism Pathology medicine.medical_specialty Neurite Basic fibroblast growth factor tau Proteins chemistry.chemical_compound Alzheimer Disease medicine Extracellular Amyloid precursor protein Neurites Humans Senile plaques Molecular Biology Aged metabolism/ultrastructure Amyloid beta-Peptides biology General Neuroscience Neurofibrillary tangle Neurofibrillary Tangles medicine.disease chemistry biology.protein pathology Neurology (clinical) Alzheimer's disease Extracellular Space Developmental Biology Neurotrophin |
| Popis: | The neurotrophic activity of beta-amyloid protein (beta-AP) has been suggested to be responsible for the dystrophic neurites that surround beta-AP deposits in senile plaques of Alzheimer disease. The recent finding that neurofibrillary tangles (NFT) that remain as remnants in the extracellular space (E-NFT) after the death of the neuron contain beta-AP, suggested that dystrophic neurites might also be associated with E-NFT. In this study, we use a probe for E-NFT, basic fibroblast growth factor (bFGF)-binding to show that E-NFT do contain dystrophic neurites. Since these neurites contain the amyloid precursor protein whose cleavage can lead to beta-AP, they may also play a role in further beta-AP deposition in the E-NFT. |
| Databáze: | OpenAIRE |
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