Plasma YKL-40 during pregnancy and gestational diabetes mellitus
| Autor: | Camilla Noelle Rathcke, Lisbeth Bonde, Filip K. Knop, Anders Rasmussen Rinnov, Tina Vilsbøll |
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| Rok vydání: | 2015 |
| Předmět: |
musculoskeletal diseases
Adult Blood Glucose medicine.medical_specialty endocrine system diseases Pregnancy Trimester Third Immunology Adipokine Inflammation Type 2 diabetes Insulin resistance Adipokines Pregnancy Internal medicine Lectins medicine Immunology and Allergy Humans Chitinase-3-Like Protein 1 Interleukin 6 biology business.industry Obstetrics Interleukin-6 nutritional and metabolic diseases Obstetrics and Gynecology Plasma levels medicine.disease female genital diseases and pregnancy complications Gestational diabetes Diabetes Gestational Endocrinology Reproductive Medicine Diabetes Mellitus Type 2 biology.protein Female medicine.symptom business Follow-Up Studies |
| Zdroj: | Journal of reproductive immunology. 112 |
| ISSN: | 1872-7603 |
| Popis: | Gestational diabetes mellitus (GDM) is characterised by hyperglycaemia during pregnancy. The clinical circumstances involved in the development of GDM leaves the patient at a high risk of the subsequent development of type 2 diabetes. Plasma levels of the inflammation marker YKL-40 are elevated in type 2 diabetes and correlate with fasting plasma glucose levels and insulin resistance in patients with type 2 diabetes. With the present study we aimed to determine if pregnancy (and associated insulin resistance) with or without GDM affects plasma YKL-40 levels. Plasma from women diagnosed with GDM and healthy normal glucose-tolerant pregnant women (non-GDM) was obtained at the third trimester of pregnancy and again 3-4 months following delivery, and levels of YKL-40 and interleukin 6 (IL-6; known to regulate YKL-40) were measured. Plasma YKL-40 levels were similarly low during pregnancy in both groups and increased significantly after delivery, but remained lower in the GDM group compared with the non-GDM group postpartum. In contrast, plasma IL-6 levels were not affected by pregnancy or diagnosis of GDM, Nevertheless, YKL-40 levels were associated with IL-6 levels in the non-GDM group (but not in the GDM group). Pregnancy seems to be associated with a temporary reduction in circulating YKL-40, which increases after delivery, but to a much lesser extent in women with GDM than in non-GDM women. |
| Databáze: | OpenAIRE |
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