Analysis of Interferon-α2 Sequences in Human Genomic DNA
| Autor: | K. Barber, S. Crowe, J. Wood, S. Macbride, D. Gewert, A. Lewis, C. Salom, H. Cooper |
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| Rok vydání: | 1993 |
| Předmět: |
Molecular Sequence Data
Immunology Alpha interferon Immunogenetics Interferon alpha-2 Biology Polymerase Chain Reaction Cell Line Virology medicine Humans Amino Acid Sequence Cloning Molecular Allele Gene Interferon alfa Genetics Base Sequence Genome Human Lymphoblast Nucleic acid sequence Interferon-alpha DNA Recombinant Proteins genomic DNA medicine.drug |
| Zdroj: | Journal of Interferon Research. 13:227-231 |
| ISSN: | 0197-8357 |
| DOI: | 10.1089/jir.1993.13.227 |
| Popis: | We have analyzed the genomic DNA sequence corresponding to the human interferon-alpha 2 (IFN-alpha 2) gene locus. In human lymphoblastoid Namalwa cells, we have detected sequences corresponding to IFN-alpha 2b and -2c, while in human KG-1 cells both IFN-alpha 2a and -2b were present. However, in 100 independent IFN-alpha 2 clones derived from 20 unrelated Caucasian volunteers, we found only sequences corresponding to IFN-alpha 2b. Statistical analysis of this result suggests that the sequences corresponding to IFN-alpha 2a and -2c are either rare allelic variants of this gene, occurring in only a minority of the Caucasian population, or are restricted to transformed cell lines. |
| Databáze: | OpenAIRE |
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