6-Hydroxylation: Effect on the Psychotropic Potency of Tryptamines
| Autor: | Irvine H. Page, Robert G. Taborsky, Peter Delvigs |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
Male
Multidisciplinary Behavior Animal Stereochemistry Metabolite Thin layer Chemistry Organic Dimethyltryptamine Metabolism Tryptamines Organic Chemistry Phenomena Rats Hydroxylation chemistry.chemical_compound chemistry Structural isomer Animals Conditioning Operant Potency Chromatography Thin Layer |
| Zdroj: | Science. 153:1018-1020 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.153.3739.1018 |
| Popis: | 6-Hydroxy-5-methoxy-N,N dimethyltryptamine and 5-methoxy-N, N-dimnethyltryptamine were synthesized and their psychotropic effects compared on trained rats in a Skinner box. The nonhydroxylated form was the more po tent. The metabolism of 5-methoxytryp tophol acetate ester was also studied to determine whether hydroxylation might occur in other than the six position with exogenous indoles. One metabolite was formed, with properties of a hydroxy-5-methoxyindole-3-acetic acid, which proved on chromatography not to be the 6-hydroxy structural isomer. Phar macologic and metabolic studies suggest that psychotropic activity of trypt amines may result from metabolites other than the 6-hydroxylated forms. |
| Databáze: | OpenAIRE |
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