| Autor: |
Michel, Martin C., Heemann, Uwe, de la Rosette, Jean J. M. C. H. |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Frontiers in Pharmacology. 13 |
| ISSN: |
1663-9812 |
| DOI: |
10.3389/fphar.2022.1081074 |
| Popis: |
While animal studies have suggested an association between the presence of hypertension and the presence and/or severity of overactive bladder syndrome (OAB) symptoms, little clinical data is available. We have conducted a pre-specified secondary analysis of a non-interventional study involving 4450 OAB patients being treated with solifenacin to explore the existence of an association between OAB and hypertension using three parallel and overlapping definitions of hypertension to enhance robustness of analysis. Regardless of definition, patients with hypertension were older and had greater OAB symptom severity in univariate analyses. In multiple regression models including age as explanatory covariate, most relationships held up but effect sizes of concomitant hypertension on OAB severity were small (odds ratios |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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