Xenopus paraxial protocadherin has signaling functions and is involved in tissue separation
Autor: | Herbert Steinbeisser, Araceli Medina, Klaus-Michael Kuerner, Rajeeb K. Swain |
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Rok vydání: | 2004 |
Předmět: |
rho GTP-Binding Proteins
Frizzled Mesoderm animal structures Xenopus Protocadherin GTPase Xenopus Proteins Biology Article General Biochemistry Genetics and Molecular Biology Receptors G-Protein-Coupled Xenopus laevis medicine Animals Protein kinase A Molecular Biology Body Patterning General Immunology and Microbiology General Neuroscience JNK Mitogen-Activated Protein Kinases Gastrula Cell sorting Cadherins biology.organism_classification Protocadherins Cell biology medicine.anatomical_structure Signal transduction Protein Binding Signal Transduction |
Zdroj: | The EMBO Journal. 23:3249-3258 |
ISSN: | 1460-2075 0261-4189 |
Popis: | Protocadherins have homophilic adhesion properties and mediate selective cell-cell adhesion and cell sorting. Knockdown of paraxial protocadherin (PAPC) function in the Xenopus embryo impairs tissue separation, a process that regulates separation of cells of ectodermal and mesodermal origin during gastrulation. We show that PAPC can modulate the activity of the Rho GTPase and c-jun N-terminal kinase, two regulators of the cytoskeletal architecture and effectors of the planar cell polarity pathway. This novel signaling function of PAPC is essential for the regulation of tissue separation. In addition, PAPC can interact with the Xenopus Frizzled 7 receptor, and both proteins contribute to the development of separation behavior by activating Rho and protein kinase Calpha. |
Databáze: | OpenAIRE |
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