Possible role of Thiazolidinedione in the management of Type-II Endometrial Cancer
| Autor: | V.V.V. Ravi Kiran Ammu, Kusuma Kumari Garikapati, Pavan Kumar Chintamaneni, Sai Kiran S.S. Pindiprolu, Praveen Thaggikuppe Krishnamurthy |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Leptin medicine.medical_specialty medicine.drug_class Adipokine Gynaecological cancer Models Biological Metastasis 03 medical and health sciences Mice 0302 clinical medicine Adipokines Internal medicine Medicine Animals Humans Resistin Thiazolidinedione Neoplasm Metastasis Cell Proliferation Adiponectin business.industry Endometrial cancer General Medicine medicine.disease Endometrial Neoplasms 030104 developmental biology Gene Expression Regulation Female Thiazolidinediones business 030217 neurology & neurosurgery |
| Zdroj: | Medical hypotheses. 126 |
| ISSN: | 1532-2777 |
| Popis: | Type-II Endometrial Cancer (EMC) is one of the most common types of gynaecological cancer affecting more than 2.7 million people worldwide. Clinical evidence shows that adipokines levels are abnormally altered in Type-II EMC and reported to be one of the major responsible factor for uncontrolled proliferation and metastasis in Type-II EMC. Reversing the altered adipokine levels, therefore, help to control Type-II EMC proliferation and metastasis. In the present hypothesis we focus on the possible role of Thiazolidinediones in favourably altering the adipokine levels to benefit in the management of Type-II EMC. |
| Databáze: | OpenAIRE |
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