Alterations in local cerebral glucose utilization induced by phencyclidine
| Autor: | Edythe D. London, Mauro Dam, Arthur D. Weissman |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty Phencyclidine Blood Pressure Deoxyglucose Somatosensory system Limbic system Internal medicine Cortex (anatomy) Deoxy Sugars medicine Animals Carbon Radioisotopes Pulse Molecular Biology Chemistry General Neuroscience Pontine nuclei Brain Psychotomimetic Rats Inbred F344 Rats Kinetics medicine.anatomical_structure Habenula Endocrinology Organ Specificity Autoradiography Neurology (clinical) Developmental Biology medicine.drug Motor cortex |
| Zdroj: | Brain Research. 435:29-40 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(87)91583-6 |
| Popis: | The effects of phencyclidine (PCP; 0.5, 1.5, 10 mg/kg, i.v.) on local cerebral glucose utilization (LCGU) in the rat were studied with the 2-deoxy- d -[1- 14 C]glucose method. Significant findings were obtained in 41 of 87 brain regions of PCP-treated rats (25–270% of control). Rates of LCGU increased throughout the limbic system, except the habenula. Although LCGU increased in most sensory structures, it decreased in specific layers of the somatosensory and auditory cortices and the inferior collicules. Evidence was seen for dissociation between LCGU responses of specific thalamic relay areas and their terminal fields in the cortex. Increases in LCGU occurred th throughout the motor system, manifesting a striking pattern of columnar activity in the motor cortex. However, LCGU was reduced in the frontal cortical pole. Elevated LCGU was onserved in the pontine nuclei and the nucleus solitarius. Effects of 5 mg/kg PCP diminished with time although 8 regions maintained a metabolic alteration at 180 min. PCP induced several behaviors, including stereotypes, which varied with the dose and time after drug administration. The results demonstrate a PCP-induced activation of various functional circuits in the brain, especially the limbic system, and may provide a physiological basis for PCP's psychotomimetic p properties. |
| Databáze: | OpenAIRE |
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