General Movement assessment and neurodevelopmental trajectory in extremely preterm infants with hypothyroxinaemia of prematurity (THOP)
| Autor: | Melissa Luig, Dimple Goel, Rajesh Maheshwari, Traci-Anne Goyen, Daphne D'Cruz |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Developmental Disabilities Infant Premature Diseases Movement assessment 03 medical and health sciences 0302 clinical medicine Corrected Age Hypothyroidism 030225 pediatrics Humans Medicine Transient hypothyroxinaemia Retrospective Studies Neurologic Examination business.industry Extremely preterm Infant Newborn Infant Obstetrics and Gynecology Retrospective cohort study Motor Skills Disorders Thyroxine Child Preschool Infant Extremely Premature Pediatrics Perinatology and Child Health Female New South Wales business 030217 neurology & neurosurgery |
| Zdroj: | Early Human Development. 144:104886 |
| ISSN: | 0378-3782 |
| Popis: | Transient hypothyroxinaemia of prematurity (THOP) has been associated with neurodevelopmental deficits with a paucity of literature leading to variable practice.Evaluation of the relationship between free T4 (fT4) levels at 2 weeks after birth and early markers of neurodevelopmental outcome.A retrospective study of prospectively collected data from infants born29 weeks' gestation, admitted to NICU between January 2012 and December 2014. The primary outcomes were the relationship between fT4 levels at 2 weeks, Prechtl General Movement Assessment (GMA) at 36 weeks and 3 months postterm age, and Bayley Scales of Infant Development (BSID-III) at 2 years postterm age. Secondary outcomes were survival free of disability and other neonatal morbidities.Of 122 infants, 101 infants had normal fT4 levels (No-THOP) and 21 had fT4 levels1SD below the mean (THOP group). There was increased frequency of abnormal GMA in the No-THOP group compared with the THOP group at 36 weeks (abnormal writhing GMs: 43% vs 21%, p = 0.15) and 3 months corrected age (absent fidgety GMs: 7.6% vs 0%, p = 0.36), though not statistically significant. The neurodevelopmental outcome was worse in the No-THOP group compared with the THOP group with significantly lower mean cognitive and motor scores at 2 year of corrected age (90 ± 13.8 vs 100 ± 8.3, p = 0.01 and 91 ± 15.2 vs 100 ± 13.2, p = 0.04 respectively).This is the first report describing General Movements (GMs) in preterm infants with THOP. We found worse neurodevelopmental outcome in No-THOP infants reflected by significantly worse cognitive and motor outcomes at 2 years corrected age. |
| Databáze: | OpenAIRE |
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