Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature
| Autor: | Michael Lim, Ariel E. Marciscano, John Laterra, Lawrence Kleinberg, Simon S. Lo, Kristin J. Redmond, Mohamed H. Khattab |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
medicine.medical_specialty Pathology Extracranial metastasis Bevacizumab business.industry Case Report Disease Aggressive disease medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens lcsh:RC254-282 Internal medicine medicine Unmethylated MGMT Promoter business medicine.drug Cause of death Glioblastoma |
| Zdroj: | Case Reports in Oncological Medicine, Vol 2015 (2015) Case Reports in Oncological Medicine |
| ISSN: | 2090-6714 2090-6706 |
| Popis: | We present a case report of a patient with glioblastoma multiforme (GBM) complicated by extracranial metastasis (ECM) whose survival of nearly four years surpassed the anticipated life expectancy given numerous negative prognostic factors including EGFRvIII-mutation, unmethylated MGMT promoter status, and ECM. Interestingly, while this patient suffered from locally aggressive disease with multiple intracranial recurrences, the proximal cause of death was progressive extracranial disease and complications related to pulmonary metastases. Herein, we review potential mechanisms of ECM with an emphasis upon glioblastoma molecular and genetic profiles and the potential implications of targeted agents such as bevacizumab. |
| Databáze: | OpenAIRE |
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