Effects of multiple sessions of antimicrobial photodynamic therapy (aPDT) in the treatment of periodontitis in patients with uncompensated type 2 diabetes: A randomized controlled clinical study
| Autor: | Lícia Clara Garcia Belizário, Letícia Helena Theodoro, Marina Módolo Cláudio, Valdir Gouveia Garcia, João Victor Soares Rodrigues, Julia Arruda Batista, Marta Aparecida Alberton Nuernberg, Cristiane Duque |
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| Přispěvatelé: | Universidade Estadual Paulista (UNESP), Latin American Institute of Dental Research and Teaching (ILAPEO) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Bleeding on probing Biophysics Dermatology Type 2 diabetes Gastroenterology Root Planing Scaling and root planing Diabetes mellitus type 2 Anti-Infective Agents Internal medicine Adjuvant therapy Medicine Humans Pharmacology (medical) Periodontitis Porphyromonas gingivalis Photosensitizing Agents biology Dental scaling business.industry Prevotella intermedia clinical trial medicine.disease biology.organism_classification Combined Modality Therapy Clinical trial Oncology Diabetes Mellitus Type 2 Photochemotherapy Chronic Periodontitis Photodynamic Therapy Dental Scaling medicine.symptom business |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2022-04-29T08:31:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-09-01 Background: The aim of this study was to compare, through clinical and microbiological analysis, the use of multiple applications of aPDT as an adjuvant therapy to non-surgical periodontal treatment of stage III and IV grade C periodontitis in type 2 diabetic (DM2) patients. Methods: Thirty-four patients with non-compensated DM2 and periodontitis were randomly divided into two groups: SRP Group (n = 17): scaling and root planing (SRP); and SRP+aPDT Group (n = 17): SRP followed by 3 consecutive aPDT applications, immediately, 48 and 96 h after in pockets with probing depth (PD) ≥5 mm. In SRP+aPDT, after 1 min of irrigation with methylene blue (10 mg/ml), the sites were irradiated with a 660 nm diode laser for 50 s (157 J/cm2, 4.7 J, 100 mW). Porphyromonas gingivalis (P. gingivalis) and Prevotella intermedia (P. intermedia) were quantified by real-time qPCR. Periodontal clinical and microbiological data (baseline, 90 and 180 days) were statistically analyzed (α = 5%). Results: There was a significant reduction in PD and bleeding on probing at 90 and 180 days post-treatment in both groups (p0.05). Conclusion: The results of present study indicate that the use of multiples aPDT sessions as adjuvant therapy in the periodontal treatment of uncompensated diabetic patients with periodontitis promotes additional clinical benefits. Department of Diagnostic and Surgery Periodontics Division São Paulo State University - UNESP Dentistry School of Araçatuba Department of Preventive and Restorative Dentistry São Paulo State University - UNESP Dentistry School of Araçatuba Latin American Institute of Dental Research and Teaching (ILAPEO) Department of Diagnostic and Surgery Periodontics Division São Paulo State University - UNESP Dentistry School of Araçatuba Department of Preventive and Restorative Dentistry São Paulo State University - UNESP Dentistry School of Araçatuba |
| Databáze: | OpenAIRE |
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