Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers
| Autor: | Mirjana Grkovic, Mirjana Rajilić-Stojanović, Milos Bjelovic, Petar S. Uskoković, Dušica B. Stojanović, Vladimir B. Pavlović |
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| Rok vydání: | 2017 |
| Předmět: |
Polymer-matrix composites (PMCs)
Materials science Thermal properties Oxide Mechanical properties 02 engineering and technology macromolecular substances 010402 general chemistry 01 natural sciences Industrial and Manufacturing Engineering Chitosan chemistry.chemical_compound Thermal stability Composite material Mechanical Engineering Prepared Material technology industry and agriculture 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Nano-structures Mechanics of Materials Nanofiber Drug delivery Ceramics and Composites 0210 nano-technology Antibacterial activity Citric acid |
| Zdroj: | Composites Part B-Engineering |
| Popis: | In this study conditions for green crosslinking with citric acid of chitosan/PEO (polyethylene oxide) nanofibers were evaluated. The thermal in situ crosslinking enabled penetration of crosslinking agent into the matrix providing an improvement of antibacterial activity, thermal stability and mechanical properties of the prepared material. With an increase of temperature above 80 °C antibacterial activity against Staphylococcus aureus and Escherichia coli, inversely decreased. Moreover crosslinking provided prolonged controlled drug release with outstanding increase of mechanical properties observed by nanoindentation measurements. Results of the investigation indicated crosslinking as an important parameter for producing material with multifunctional characteristics suitable for drug delivery and tissue engineering. |
| Databáze: | OpenAIRE |
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