On-demand controlled release of anti-inflammatory and analgesic drugs from conducting polymer films to aid in wound healing
| Autor: | June-Ho Jung, Joseph Mbugua, Siqiang Zhu, Mark Chase, Theodore R. Nicholson, Ramil Mercado, Gusphyl Justin, Jeffrey Maskrod |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Drug
Polymers media_common.quotation_subject Analgesic Ibuprofen Polypyrrole Cell Line chemistry.chemical_compound Drug Delivery Systems Materials Testing Humans Pyrroles Electrodes media_common chemistry.chemical_classification Conductive polymer Wound Healing Chemistry Anti-Inflammatory Agents Non-Steroidal Membranes Artificial Polymer Analgesics Non-Narcotic Controlled release Drug delivery Wound healing Biomedical engineering |
| Zdroj: | EMBC |
| DOI: | 10.1109/embc.2012.6346153 |
| Popis: | An electronically-controlled drug delivery system (eDDS) for the on-demand release of anti-inflammatory, anti-microbial and analgesic agents to aid in wound healing is currently under development. The loading of several drugs into conductive polymer films and their subsequent on-demand, controlled release upon application of an electrical potential to the polymer film has been demonstrated. The loading and release (active and passive) of Ibuprofen sodium salt - a negatively charged analgesic and anti-inflammatory agent - from polypyrrole films is described. Major challenges identified include precise control over drug loading and passive release from the conducting polymers in the absence of an applied potential. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|