Diffuse Thyroid Uptake Incidentally Found on 18F-Fluorodeoxyglucose Positron Emission Tomography in Subjects without Cancer History
| Autor: | Seung Hyup Hyun, Su Jin Jang, Yearn Seong Choe, Byung Tae Kim, Seung Hwan Moon, Yoon-Ho Choi, Kyung-Han Lee, Joon Young Choi, Ji Young Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Positron emission tomography Thyroid Gland Thyrotropin Thyroid function tests Gastroenterology Diffuse thyroid uptake Antibodies Young Adult Thyroid-stimulating hormone Fluorodeoxyglucose F18 Internal medicine Microsomes Neoplasms Medicine Humans Radiology Nuclear Medicine and imaging Clinical significance Pathological 18F-Fluorodeoxyglucose Aged Retrospective Studies Ultrasonography Aged 80 and over Incidental Findings Triiodothyronine medicine.diagnostic_test business.industry Thyroid Cancer Middle Aged medicine.disease Autoimmune thyroid disease medicine.anatomical_structure Positron-Emission Tomography Original Article Female Nuclear Medicine Radiopharmaceuticals business Nuclear medicine |
| Zdroj: | Korean Journal of Radiology |
| ISSN: | 2005-8330 1229-6929 |
| Popis: | OBJECTIVE We investigated the clinical significance of incidental diffuse thyroid uptake (DTU) on (18)F-FDG PET in subjects without a history of cancer. MATERIALS AND METHODS This study included 2062 studies from adults who underwent (18)F-FDG PET as a cancer screening program. Subjects were divided into the following two groups: with (group I) or without (group II) DTU. The presence of DTU and the thyroid visual grading score were compared with thyroid function tests, serum anti-microsomal antibody (AMA) levels, and the presence of diffuse parenchymal change (DPC) on ultrasonography (USG). RESULTS DTU was found in 6.6% of the scans (137/2062). Serum thyroid stimulating hormone (TSH) and AMA levels were significantly higher in group I than in group II. Increased AMA level (55.1%) and DPC (48.7%) were more frequently found in group I (p < 0.001). The proportion of subjects with any abnormal results in serum free thyroxine, triiodothyronine, TSH, or AMA levels or DPC on USG was significantly higher in group I than in group II (71.5% vs. 10.6%, p < 0.001), and was significantly and gradually increased according to the visual grading score group (0 vs. 1-2 vs. 3-4 = 10.6% vs. 58.5% vs. 90.9%, p < 0.001). TSH and is AMA levels were significantly increased according to the visual grading score. CONCLUSION The presence or degree of incidental DTU on (18)F-FDG PET is closely correlated with increased serum AMA and TSH levels, and the presence of DPC on USG. Therefore, the most plausible pathological cause of DTU may be cell damage by an autoimmune mechanism. |
| Databáze: | OpenAIRE |
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