Systemic and endotracheal antibiotic prophylaxis of nosocomial pneumonia in ICU
| Autor: | B. Kemmerich, T. Schaberg, Höffken G, Hartmut Lode |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Modern medicine
medicine.medical_specialty Clinical Trials as Topic Cross Infection medicine.drug_class business.industry Administration Topical Antibiotics Placebo-controlled study Pneumonia Critical Care and Intensive Care Medicine medicine.disease Hospital-acquired pneumonia Anti-Bacterial Agents Intensive care medicine Humans Gentamicin Infusions Parenteral Antibiotic prophylaxis Gentamicins business Intensive care medicine medicine.drug |
| Zdroj: | Intensive care medicine. 18 |
| ISSN: | 0342-4642 |
| Popis: | Nosocomial pneumonias, especially in ventilated patients, are a continuing problem in modern medicine. Pathogens most commonly involved with these pneumonias are Enterobacteriaceae, Ps. aeruginosa and S. aureus. Several prevention measures for nosocomial pneumonia are possible such as parenteral and topical antibiotics--a very controversial issue. Several studies with parenteral antibiotics, starting as early as 1954, could not prove any benefit of parenteral antibiotics in pneumonia prevention. Topical antibiotics, starting with polymyxin or gentamicin via the endotracheal tube in the 70s, gave controversial results. In a prospective, randomized, double-blind placebo controlled study with gentamicin via the endotracheal tube in ventilated ICU patients we found no significant reduction of pneumonia rate and mortality. However, the combined approach (SDD) of oropharyngeal, gastrointestinal and parenteral use of certain antibiotics appears to give promising results in specific patient subgroups such as ventilated polytrauma patients in ICU. |
| Databáze: | OpenAIRE |
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