Coding triplets in the tRNA acceptor-TΨC arm and their role in present and past tRNA recognition
| Autor: | Itay Fayerverker, Ilana Agmon, Tal Mor |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Biophysics
Aminoacylation Biology Peptide Elongation Factor Tu Biochemistry Amino Acyl-tRNA Synthetases Evolution Molecular 03 medical and health sciences RNA Transfer Structural Biology Genetics Escherichia coli Nucleotide Amino Acids Codon Molecular Biology 030304 developmental biology chemistry.chemical_classification 0303 health sciences Translation system 030302 biochemistry & molecular biology Translation (biology) Cell Biology Genetic code Amino acid Elongation factor chemistry Genetic Code Transfer RNA Nucleic Acid Conformation |
| Zdroj: | FEBS lettersReferences. 595(7) |
| ISSN: | 1873-3468 |
| Popis: | The mechanism and evolution of the recognition scheme between key components of the translation system, that is, tRNAs, synthetases, and elongation factors, are fundamental issues in understanding the translation of genetic information into proteins. Statistical analysis of bacterial tRNA sequences reveals that for six amino acids, a string of 10 nucleotides preceding the tRNA 3' end carries cognate coding triplets to nearly full extent. The triplets conserved in positions 63-67 are implicated in the recognition by the elongation factor EF-Tu, and those conserved in positions 68-72, in the identification of cognate tRNAs, and their derived minihelices by class IIa synthetases. These coding triplets are suggested to have primordial origin, being engaged in aminoacylation of prebiotic tRNAs and in the establishment of the canonical codon set. |
| Databáze: | OpenAIRE |
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