The effect of airway pressure and oscillation amplitude on ventilation in pre-term infants
| Autor: | Frans H.C. de Jongh, Anton H. van Kaam, Martijn Miedema, Inéz Frerichs, Mariëtte B. van Veenendaal |
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| Přispěvatelé: | Neonatology, ARD - Amsterdam Reproduction and Development, Faculty of Engineering Technology |
| Rok vydání: | 2012 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Time Factors Functional Residual Capacity METIS-302746 Pulmonary compliance chemistry.chemical_compound Surface-Active Agents Functional residual capacity IR-91045 Internal medicine Oscillometry Electric Impedance Pressure Medicine Humans Lung volumes Respiratory system Lung Lung Compliance Tomography Respiratory Distress Syndrome Newborn Models Statistical business.industry Oscillation Infant Newborn Respiratory Function Tests Oxygen chemistry Volume (thermodynamics) Anesthesia Carbon dioxide Breathing Cardiology business Infant Premature |
| Zdroj: | European respiratory journal, 40(2), 479-484. European Respiratory Society |
| ISSN: | 1399-3003 0903-1936 |
| Popis: | We determined the effect of lung recruitment and oscillation amplitude on regional oscillation volume and functional residual capacity (FRC) in high-frequency oscillatory ventilation (HFOV) used in pre-term infants with respiratory distress syndrome (RDS). Changes in lung volume, oscillation volume and carbon dioxide levels were recorded in 10 infants during a stepwise recruitment procedure, and an increase in pressure amplitude of 5 cmH(2)O was measured using electrical impedance tomography and transcutaneous monitoring. The pressures at maximal respiratory system compliance, maximal oscillation volume and minimal carbon dioxide levels were determined. Impedance data were analysed for the chest cross-section and predefined regions of interest. Despite the fixed pressure amplitude, the oscillation volume changed during the incremental pressure steps following a parabolic pattern, with an inverse relationship to the carbon dioxide pressures. The pressures corresponding with maximal compliance, maximal oscillation volume and minimal carbon dioxide were similar and highly correlated. Regional analysis showed similar findings. The increase in pressure amplitude resulted in increased oscillation volumes and decreased carbon dioxide levels, while FRC remained unchanged. In HFV pre-term infants with RDS, oscillation volumes are closely related to the position of ventilation in the pressure-volume envelope and the applied pressure amplitude. Changes in pressure amplitude do not seem to affect FRC. |
| Databáze: | OpenAIRE |
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