Chronic bacterial pulmonary infections in advanced cystic fibrosis differently affect the level of sputum neutrophil elastase, IL-8 and IL-6
| Autor: | Grzegorz Majka, Edyta Golińska, Magdalena Strus, Marta Ciszek-Lenda, Agnieszka Pac, Janusz Marcinkiewicz, Henryk Mazurek, Rafał Szatanek |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Adolescent Cystic Fibrosis Immunology Inflammation Cystic fibrosis Young Adult 03 medical and health sciences 0302 clinical medicine Forced Expiratory Volume medicine Humans Immunology and Allergy Pseudomonas Infections Lymphocyte Count Child Respiratory Tract Infections Lung biology medicine.diagnostic_test Interleukin-6 business.industry Interleukin-8 Elastase Sputum Interleukin medicine.disease Interleukin-10 respiratory tract diseases C-Reactive Protein 030104 developmental biology Bronchoalveolar lavage medicine.anatomical_structure Biofilms Neutrophil elastase Pseudomonas aeruginosa biology.protein Female ORIGINAL ARTICLES Inflammation Mediators medicine.symptom Leukocyte Elastase business Biomarkers 030215 immunology |
| Zdroj: | Clin Exp Immunol |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1111/cei.13624 |
| Popis: | Advanced cystic fibrosis (CF) lung disease is commonly characterized by a chronic Pseudomonas aeruginosa infection and destructive inflammation caused by neutrophils. However, the lack of convincing evidence from most informative biomarkers of severe lung dysfunction (SLD-CF) has hampered the formulation of a conclusive, targeted diagnosis of CF. The aim of this study was to determine whether SLD-CF is related to the high concentration of sputum inflammatory mediators and the presence of biofilm-forming bacterial strains. Forty-one patients with advanced CF lung disease were studied. The severity of pulmonary dysfunction was defined by forced expiratory volume in 1 second (FEV1) |
| Databáze: | OpenAIRE |
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