Improving biobehavioral health in younger breast cancer survivors: Pathways to Wellness trial secondary outcomes
| Autor: | Julienne E Bower, Ann H Partridge, Antonio C Wolff, Steve W Cole, Michael R Irwin, Elissa D Thorner, Hadine Joffe, Laura Petersen, Catherine M Crespi, Patricia A Ganz |
|---|---|
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | JNCI: Journal of the National Cancer Institute. 115:83-92 |
| ISSN: | 1460-2105 0027-8874 |
| DOI: | 10.1093/jnci/djac180 |
| Popis: | Background The Pathways to Wellness trial tested the efficacy of 2 interventions for younger breast cancer survivors: mindful awareness practices (MAPs) and survivorship education (SE). This planned secondary analysis examines intervention effects on stress, positive psychological outcomes, and inflammation (Clincaltrials.gov NCT03025139). Methods Women diagnosed with breast cancer at or before age 50 years who had completed treatment and had elevated depressive symptoms were randomly assigned to 6 weeks of MAPs, SE, or wait-list control (WLC). Assessments conducted at pre- and postintervention and at 3- and 6-month follow-up measured general stress perceptions, cancer-related intrusive thoughts and worry, positive affect, meaning and peace in life, altruism and empathy, and markers of inflammation. Analyses compared change in outcomes over time in each intervention group relative to WLC using linear mixed models. Results A total 247 women were randomly assigned to MAPs (n = 85), SE (n = 81), or WLC (n = 81). MAPs statistically significantly decreased intrusive thoughts and worry at postintervention and 3-month follow-up relative to WLC (P Conclusion MAPs had beneficial effects on psychological and immune outcomes in younger breast cancer survivors and is a promising approach for enhancing biobehavioral health. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|