Roles of angiogenic factors and endothelin-1 in gastric ulcer healing

Autor: Mutsuo Shigemoto, Hiroshi Hashimoto, Masumi Akimoto, Katsuko Yamashita, Atsushi Maeda
Rok vydání: 2002
Předmět:
Vascular Endothelial Growth Factor A
medicine.hormone
Receptors
CXCR4
medicine.medical_specialty
Endothelium
Angiogenesis
Neovascularization
Physiologic
Endothelial Growth Factors
Biology
Helicobacter Infections
Endothelins
chemistry.chemical_compound
Internal medicine
medicine
Gastric mucosa
Humans
Stomach Ulcer
CXC chemokine receptors
Growth Substances
Receptor
Extracellular Matrix Proteins
Lymphokines
Vascular Endothelial Growth Factor Receptor-1
Endothelin-1
Helicobacter pylori
Receptors
Endothelin
Reverse Transcriptase Polymerase Chain Reaction
Vascular Endothelial Growth Factors
General Medicine
Receptor
Endothelin A
Immunohistochemistry
Endothelin 1
Chemokine CXCL12
Vascular endothelial growth factor
medicine.anatomical_structure
Endocrinology
chemistry
Gastric Mucosa
Intercellular Signaling Peptides and Proteins
Chemokines
CXC
Zdroj: Clinical Science. 103:450S-454S
ISSN: 0143-5221
DOI: 10.1042/cs103s450s
Popis: Endothelins (ETs) participate directly and indirectly in angiogenesis via ET receptors. During early fetal angiogenesis, vascular endothelial growth factor (VEGF) and its receptors kinase insert domain-containing receptor (KDR) and fms-like tyrosine kinase-1 (Flt-1) are required for the development of the systemic vasculature. In late angiogenesis, stromal-cell-derived factor (SDF-1) and its receptor CXC chemokine receptor 4 (CXCR4) act in an organ-specific manner to promote the formation and development of large blood vessels supplying the gastrointestinal tract. We studied the roles of these ligand receptors in angiogenesis during healing of gastric ulcers. We studied the following five groups, each consisting of ten cases of endoscopically confirmed gastric ulcer: active stage (GA), healing stage (GH) and scar stage (GS) of gastric ulcers located in the angulus; Helicobacter pylori (Hp)-positive gastritis (gast+); and Hp-negative gastritis (gast-). All cases in the ulcer groups were Hp-positive. The study materials consisted of frozen biopsy specimens of lesions arising in the angulus. ET-1 was measured by enzyme immunoassay. The other factors were assayed by reverse-transcription–PCR. The distributions of ET-1, ETA receptor (ETAR), SDF-1 and CXCR4 in the gastric mucosa were evaluated by enzyme immunoassay. ET-1 and ETAR reached peak levels during the GH (ET: P
Databáze: OpenAIRE
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