Additional file 1: Fig. S1. of Lentiviral vector-mediated overexpression of mutant ataxin-7 recapitulates SCA7 pathology and promotes accumulation of the FUS/TLS and MBNL1 RNA-binding proteins

Autor: Alves, Sandro, Marais, Thibaut, Maria-Grazia Biferi, Furling, Denis, Marinello, Martina, Hachimi, Khalid El, Cartier, Nathalie, Ruberg, Merle, Stevanin, Giovanni, Brice, Alexis, Barkats, Martine, Sittler, Annie
Rok vydání: 2016
Předmět:
DOI: 10.6084/m9.figshare.c.3618638_d2
Popis: Lentiviral-mediated overexpression of the Green Fluorescent Protein (GFP) in the mouse cerebellum. Fig. S2. Overexpression of truncated MUT ATXN7 in the mouse cerebellum induces the formation of ubiquitinated ATXN7 aggregates Fig. S3. Lentiviral-mediated overexpression MUT ATXN7 in the mouse cerebellum, at 2Â weeks post-infection (early time point). Fig. S4. Phosphorylated TDP-43 expression in the cerebellum of Atxn7 100Q/5Q KI mice. Fig. S5. FUS/TLS is trapped in ATXN7 aggregates in Atxn7 100Q/5Q KI mice. Fig. S6. MBNL1 and MBNL2 immunoreactivity and expression in the cerebellum of Atxn7 100Q/5Q KI mice. (PDF 1053Â kb)
Databáze: OpenAIRE