Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study
| Autor: | Craig Arrowitz, Irena Angelova-Fischer, Teresa M. Weber, Frank Rippke, Detlef Zillikens, Daniel Richter, Tobias W. Fischer, Alexander Filbry |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Time Factors Erythema medicine.medical_treatment law.invention 030207 dermatology & venereal diseases 0302 clinical medicine Randomized controlled trial law Recurrence lcsh:Dermatology Prospective Studies Young adult Prospective cohort study Skin Remission Induction General Medicine Atopic dermatitis Middle Aged skinbarrier Treatment Outcome 030220 oncology & carcinogenesis Disease Progression licochalconeA Female Steroids medicine.symptom Topical steroid Adult medicine.medical_specialty Dermatology Administration Cutaneous Drug Administration Schedule Dermatitis Atopic 03 medical and health sciences Young Adult atopicdermatitis Double-Blind Method medicine Humans business.industry Pruritus Antipruritics lcsh:RL1-803 medicine.disease emollients Discontinuation omega-6fattyacids Concomitant maintenancetreatment business |
| Zdroj: | Acta Dermato-Venereologica, Vol 98, Iss 5, Pp 517-523 (2018) |
| ISSN: | 1651-2057 0001-5555 |
| Popis: | Prevention of the flares is a main goal in the long-term treatment of atopic dermatitis (AD). Therefore we investigated the efficacy of a water-in-oil emollient, containing licochalcone A, omega-6-fatty acids, ceramide 3 and glycerol, for prevention of the flares in adults with mild to moderately severe AD, treated with topical steroids, that led to clearing of the inflammatory lesions and had been discontinued prior to inclusion. The study was a 12-week, double-blind, randomized, vehicle-controlled, left-right comparison test with the number of relapses, defined as re-occurrence of erythema for at least 3 consecutive days, considered the primary outcome. Compared with the vehicle, the active formulation significantly reduced the number of relapses and maintained the barrier homeostasis of the respective arm. To the best of knowledge, this is the first study to show prevention of the AD flares by the use of stand-alone emollient treatment, based on comparison with the corresponding vehicle while excluding concomitant/rescue medications. |
| Databáze: | OpenAIRE |
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